940903-63-9Relevant academic research and scientific papers
A facile synthesis of 4-gem-difluoromethylene β-lactam and its derivatives from BrCF2CF2Br
Wang, Hui,Zhu, Shifa,Xing, Chunhui,Pang, Wan,Deng, Qinying,Zhu, Shizheng
, p. 1195 - 1203 (2008/09/19)
4-Bromodifluoromethyl β-lactams 2 are prepared from the commercial available BrCF2CF2Br in overall five-step reaction procedure. Under the radical reaction conditions (Bu3SnH/AIBN), compound 2 reacted with alkenes affording to the corresponding addition product difluoromethylene β-lactams 7. In the absence of alkenes, it can be converted into the corresponding difluoromethyl β-lactam 6 in almost quantitative yield. Furthermore, allylic stannic reagent Bu3SnCH2CH{double bond, long}CH2 reacted with 2 under the same reaction conditions gave the allylic addition product 8.
