940943-34-0Relevant academic research and scientific papers
Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions
Lange, Jos H.M.,Verveer, Peter C.,Osnabrug, Stefan J.M.,Visser, Geb M.
, p. 1367 - 1369 (2007/10/03)
3-Aryl-4-hydroxyquinolin-2(1H)-ones are potent and selective glycine-site NMDA receptor antagonists of pharmaceutical interest. A novel microwave-enhanced synthesis of such quinolinones under solvent-free conditions has been developed. The quinolinones ar
Hydroxyquinolone derivatives compounds which have pharmaceutical utility
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, (2008/06/13)
This present invention relates to a class of 4-hydroxy-2-(1H)-quinolones which are substituted in the 3-position by an optionally substituted aryl substituent. These compounds are selective non-competitive antagonists of N-methyl-D-aspartate (NMDA) receptors.
