940951-99-5 Usage
Uses
Used in Bioconjugation:
t-Boc-N-Amido-PEG4-Azide is used as a bioconjugation agent for attaching biomolecules to other chemical entities or surfaces. The PEG4 spacer provides a hydrophilic and flexible linkage, while the azide group enables efficient click chemistry with alkyne-containing compounds, such as BCN or DBCO.
Used in Drug Delivery Systems:
In the pharmaceutical industry, t-Boc-N-Amido-PEG4-Azide is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEGylation of drugs can reduce immunogenicity and increase circulation time in the body, while the Boc-protected amine allows for controlled release or activation under specific conditions.
Used in Chemical Synthesis:
t-Boc-N-Amido-PEG4-Azide is used as an intermediate in the synthesis of complex organic molecules, where the PEG chain can serve as a spacer or a solubilizing group. The azide functionality can be employed in click chemistry for the assembly of larger structures or for the introduction of various functional groups.
Used in Materials Science:
In materials science, t-Boc-N-Amido-PEG4-Azide is used for the functionalization of surfaces and the creation of stimuli-responsive materials. The PEG chain can provide non-fouling properties, while the azide group can be used for orthogonal click chemistry to introduce specific functionalities or to create dynamic materials that respond to environmental changes.
Check Digit Verification of cas no
The CAS Registry Mumber 940951-99-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,0,9,5 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 940951-99:
(8*9)+(7*4)+(6*0)+(5*9)+(4*5)+(3*1)+(2*9)+(1*9)=195
195 % 10 = 5
So 940951-99-5 is a valid CAS Registry Number.
940951-99-5Relevant academic research and scientific papers
Synthesis method of NH2-PEG5-NHBoc
-
Paragraph 0058; 0067-0069; 0073; 0082-0084; 0088; 0097-0099, (2021/10/11)
The invention provides a synthesis method of NH2-PEG5-NHBoc. The NH2-PEG5-NHBoc represents [2-(2-{2-[2-(2-amino-ethyoxyl)ethyoxyl]ethyoxyl}ethyoxyl)ethyl]carbamic acid tert-butyl ester. The synthesis method comprises the following steps: step S1, by taking 2-(2-(triphenylmethyl)ethyoxyl)-1-ol and (2-(2-(2-(benzyloxy)ethyoxyl)ethyoxyl)-ethyl-4-p-toluenesulfonate as initial raw materials, carrying out substitution reaction to generate a first intermediate product; S2, carrying out catalytic hydrogenation on the first intermediate product and hydrogen, and then carrying out nucleophilic substitution reaction with Boc anhydride to generate a second intermediate product; S3, carrying out nucleophilic substitution reaction on the second intermediate product and paratoluensulfonyl chloride to generate a third intermediate product; S4, carrying out nucleophilic substitution reaction on the third intermediate product and sodium azide to generate a fourth intermediate product; and S5, carrying out a reduction reaction on the fourth intermediate product and hydrogen, so as to generate the NH2-PEG5-NHBoc. The synthesis method is low in cost and high in yield.
