94109-78-1

Basic information

• Product Name: 3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]thioxanthene]-3-one
• Synonyms: 3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]thioxanthene]-3-one;3',6'-Dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]-thioxanthen]-3-one;3',6'-Dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]thioxanthen]-3-one
• CAS NO: 94109-78-1
• Molecular Formula: C₂₀H₁₂O₄S
• Molecular Weight: 348.37188
• EINECS: 302-518-5
• Mol File: 94109-78-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 641.6°Cat760mmHg
• Flash Point: 341.9°C
• Appearance: /
• Density: 1.61g/cm³
• CAS DataBase Reference: 3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]thioxanthene]-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]thioxanthene]-3-one(94109-78-1)
• EPA Substance Registry System: 3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]thioxanthene]-3-one(94109-78-1)

Safety Data

• Hazardous Substances Data: 94109-78-1(Hazardous Substances Data)

Upstream product

• 2321-07-5 fluorescein 
• 85-44-9 phthalic anhydride 
• 63572-32-7 3,3'-dihydroxyldiphenyl sulfide 
• 134953-13-2 1-methoxy-3-[(3-methoxyphenyl)sulfanyl]benzene 
• 15570-12-4 3-methoxybenzenethiol 
• 766-85-8 3-methoxy-1-iodobenzene 

Downstream Products

• 2513-33-9 2-(2,4-dihydroxybenzoyl)benzoic acid 

Relevant articles and documents

Improved synthesis of thiofluorescein

Thiofluorescein was synthesized in a preparative yield by successive demethylation of 3,3′-dimethoxydiphenyl sulfide to 3,3′- dihydroxydiphenyl sulfide and condensation of the latter with phthalic anhydride in H2SO4. The title compound was also obtained in a higher yield from 3,3′-dimethoxydiphenyl sulfide directly in a one-pot process combining the condensation in H2SO4 and demethylation in 2 Py·H2SO4. 2005 Pleiades Publishing, Inc.