94112-85-3

Upstream product

• 108-30-5 succinic acid anhydride 
• 2944-47-0 o-isopropylanisole 
• 88-69-7 2-(1-methylethyl)phenol 
• 1025911-50-5 4-(3-Isopropyl-4-methoxy-phenyl)-4-oxo-butyric acid ethyl ester 
• 106165-94-0 4-(4-hydroxy-3-isopropyl-phenyl)-4-oxo-butyric acid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 39863-61-1 4-(3'-Isopropyl-4'-methoxyphenyl)butyric acid 
• 22009-41-2 6-isopropyl-7-methoxy-3,4-dihydronaphthalen-1(2H)-one 
• 1026404-82-9 4-(3-Isopropyl-4-methoxy-phenyl)-butyryl chloride 
• 1026632-48-3 4-[6-Isopropyl-7-methoxy-1-oxo-3,4-dihydro-1H-naphthalen-(2E)-ylidenemethyl]-benzoic acid methyl ester 
• 1027933-81-8 4-[Hydroxy-(6-isopropyl-7-methoxy-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid methyl ester 
• 1026392-96-0 4-[Hydroxy-(7-isopropoxy-6-isopropyl-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid methyl ester 
• 27210-57-7 miltirone 
• 116064-77-8 1,2-didehydromiltirone 
• 109512-98-3 4-(3-isopropyl-4-methoxy-phenyl)-butyric acid methyl ester 
• 33537-78-9 4-Methoxy-3-isopropylbenzoic acid 

Relevant academic research and scientific papers

Structure Elucidation and Total Synthesis of New Tanshinones Isolated from Salvia miltiorrhiza Bunge (Danshen)

Totally 11 new compounds have been isolated from the dried root of Salvia miltiorrhiza Bunge "Danshen" and their structures were elucidated by means of spectrometric methods.The total syntheses of two new compounds, namely, 1,2-didehydromiltirone and 4-methylenemiltirone, are also reported.

Diisobutylaluminum hydride-promoted cyclization of silylated 1,3-dien-5-ynes: Application to total synthesis of a 20-norabietane derivative

The diisobutylaluminum hydride (DIBAL-H)-promoted benzocyclization, recently developed by this group, was adopted for the synthesis of a natural product containing a 9,10-dihydrophenanthrene skeleton to demonstrate its synthetic utility. One of the extrac

A novel type of retinoic acid receptor antagonist: Synthesis and structure-activity relationships of heterocyclic ring-containing benzoic acid derivatives

A new series of heterocyclic ring-containing benzoic acids was prepared, and the binding affinity and antagonism of its members against all-trans- retinoic acid were evaluated by in vitro assay systems using human promyelocytic leukemia (HL-60) cells. Structure-activity relationships indicated that both an N-substituted pyrrole or pyrazole (1-position) and a hydrophobic region, with these linked by a ring system, were indispensable for effective antagonism. Among the compounds evaluated, optimal antagonism was exhibited by 4-[4,5,7,8,9,10-hexahydro-7,7,10,-10-tetramethyl-1-(3- pyridylmethyl)anthra[1,2-b]pyrrol-3-yl]benzoic acid (31), 4-[4,5,7,8,9,10- hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)-5-thiaanthra[1,2- b]pyrrol-3-yl]benzoic acid (40), and 4-[4,5,7,8,9,10-hexahydro-7,7,10,10- tetramethyl-1-(3-pyridylmethyl)anthra[2,1-d]pyrazol-3-yl]benzoic acid (55), all of which possess a 3-pyridylmethyl group at the five-membered ring nitrogen atom.

TOTAL SYNTHESIS OF (+/-)-SHONANYL METHYL ETHER AND (+/-)-FERRUGINYL METHYL ETHER

An efficient reductive methylation of the tricyclic ketone 12 in anhydrous ammonia provided the β,γ-unsaturated ketone 15 in high yield wich was subsequently converted into (+/-)-shonanyl methyl ether (3) and (+/-)-ferruginyl methyl ether (6).