94127-09-0

Basic information

• Product Name: 9H-Carbazol-3-amine, 9-(phenylmethyl)-
• Synonyms: 3-amino-9-benzylcarbazole;9H-Carbazol-3-amine,9-(phenylmethyl);9-(phenylmethyl)-9H-carbazole-3-amine
• CAS NO: 94127-09-0
• Molecular Formula: C19H16N2
• Molecular Weight: 272.349
• Mol File: 94127-09-0.mol

Chemical Properties

• CAS DataBase Reference: 9H-Carbazol-3-amine, 9-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Carbazol-3-amine, 9-(phenylmethyl)-(94127-09-0)
• EPA Substance Registry System: 9H-Carbazol-3-amine, 9-(phenylmethyl)-(94127-09-0)

Safety Data

• Hazardous Substances Data: 94127-09-0(Hazardous Substances Data)

Upstream product

• 94127-10-3 9-benzyl-3-nitro-9H-carbazole 
• 3077-85-8 3-Nitro-carbazol 
• 86-74-8 9H-carbazole 
• 100-44-7 benzyl chloride 
• 19402-87-0 9-benzyl-9H-carbazole 

Downstream Products

• 138963-55-0 9-benzyl-3-carbethoxyamino carbazole 
• 94127-16-9 (9-Benzyl-9H-carbazol-3-yl)-dimethyl-amine 
• 94127-26-1 3-(N,N-dimethylamino)-4-nitro-9-benzylcarbazole 
• 138963-63-0 9-benzyl-3,4-diaminocarbazole 
• 138963-60-7 9-Benzyl-4-nitro-9H-carbazol-3-ylamine 
• 138963-67-4 6-benzyl-2-(2-furyl)-1(3)H-imidazo<4,5-c>-carbazole 
• 138963-65-2 6-benzyl-2-methoxycarbonylamino-1(3)H-imidazo<4,5-c>carbazole 
• 138963-61-8 3-amino-9-benzyl-4,6-dinitrocarbazole 
• 138963-57-2 9-benzyl-3-carbethoxyamino-4-nitro carbazole 
• 138963-58-3 3-carbethoxyamino-4,6-dinitro-9-benzylcarbazole 
• 924637-17-2 2-amino-N-(9-benzyl-9H-carbazol-3-yl)benzamide hydrochloride 
• 1234193-63-5 7-benzyl-1,3-diphenyl-7H-pyrido[2,3-c]carbazole 
• 1353648-70-0 diethyl 1,3-bis(9-benzyl-9H-carbazol-3-yl)-1,2,3,6-tetrahydro-4,5-pyrimidinedicarboxylate 
• 1353648-62-0 ethyl 4-(9-benzyl-9H-carbazol-3-ylamino)-2-(4-nitrophenyl)-5-oxo-2,5-dihydro-3-furancarboxylate 

Relevant articles and documents

Design, Synthesis and Discovery of N,N’-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure-based virtual screening approach using the ZIKV NS5-MTase. A novel series of molecules with a carbazoyl-aryl-urea structure has been discovered and a library of analogues has been synthesized. The new compounds inhibit ZIKV MTase with IC50 between 23–48 μM. In addition, carbazoyl-aryl-ureas also proved to inhibit ZIKV replication activity at micromolar concentration.

Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120°C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.

Carbazole N-substituent effect upon DTMA: Stabilizing and photochromic modulating

Dithienylmaleimide derivatives 7-27 were synthesized by introducing N-substituted carbazole for photo-stabilizing purpose, and the structures were fully confirmed. The photochromism and photo-stability were recorded via UV-vis spectra. Only ortho compounds 8-17 with N-substituents on carbazole moiety showed escalated photochromic change, while compound 7 and the para counterparts 18-27 showed no appreciable photochromism. Additionally, compounds 8-18 exhibited good photo-stability except 17 under 254 nm irradiation. The unstability of 17 may probably due to overrunning hindrance. These photochromic patterns indicated that hindrance and electronic effect mutually paid a decisive influence on the photochromism and photo-stability, which potentially exploited a new way to construct novel photochromic materials with regulable and conceivable performance.

3-Aminocarbazole Compounds, Pharmaceutical Composition Containing the Same and Method for the Preparation Thereof

A compound of formula (I), in which R1, R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.

3-AMINOCARBAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR THE PREPARATION THEREOF

A compound of formula (I), in which R1 , R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.

Antiparasitic agents: Part XIV -- Synthesis of 2,6-disubstituted-1(3)H-imidazocarbazoles as anthelmintic agents

Substituted 9-benzyl/methylcarbazoles (2-17) and 6-benzyl/methyl-2-furyl/methoxycarbonylamino-1(3)H-imidazocarbazoles (18-21) have been synthesized and screened for their antifilarial, anthelminitic and antiamoebic activities against Litomosoides carini, Acanthocheilonema viteae, Acylostoma ceylanicum, Nippostrongylus brasiliensis, Hymenolepis nana and Entamoeba histolytica.No significant activity has been observed.

N-METHYL DERIVATIVES OF 3-AMINOCARBAZOLE

Methylation of 3-aminocarbazole in presence of sodium hydrogencarbonate yields carbazolyl-3-trimethylammonium iodide, in alkaline media the fourth methyl group is introduced. 3-(N,N-Dimethylamino)-carbazoles were obtained from corresponding methiodides by lithium aluminium hydride reduction or by thermal decomposition.Synthesis of 3-(N-methylamino)-carbazole via tosylamide failed because of 3-(N-methyltosylamino)-9-tosylcarbazole cleaved only one sulfonamide bond.The method involving formylation of 3-aminocarbazole and reduction of the amide gave satisfactory results.