94127-10-3

Basic information

• Product Name: 9H-Carbazole, 3-nitro-9-(phenylmethyl)-
• CAS NO: 94127-10-3
• Molecular Formula: C19H14N2O2
• Molecular Weight: 302.332
• Mol File: 94127-10-3.mol

Chemical Properties

• CAS DataBase Reference: 9H-Carbazole, 3-nitro-9-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-Carbazole, 3-nitro-9-(phenylmethyl)-(94127-10-3)
• EPA Substance Registry System: 9H-Carbazole, 3-nitro-9-(phenylmethyl)-(94127-10-3)

Safety Data

• Hazardous Substances Data: 94127-10-3(Hazardous Substances Data)

Upstream product

• 3077-85-8 3-Nitro-carbazol 
• 100-44-7 benzyl chloride 
• 19402-87-0 9-benzyl-9H-carbazole 
• 100-51-6 benzyl alcohol 
• 86-74-8 9H-carbazole 

Downstream Products

• 94127-09-0 9-benzyl-9H-carbazol-3-amine 
• 95600-16-1 Bis-(9-benzyl-9H-carbazol-3-yl)-diazene 
• 95600-21-8 C₃₈H₂₆N₄ 
• 94127-16-9 (9-Benzyl-9H-carbazol-3-yl)-dimethyl-amine 
• 94127-26-1 3-(N,N-dimethylamino)-4-nitro-9-benzylcarbazole 
• 138963-63-0 9-benzyl-3,4-diaminocarbazole 
• 138963-60-7 9-Benzyl-4-nitro-9H-carbazol-3-ylamine 
• 138963-55-0 9-benzyl-3-carbethoxyamino carbazole 
• 138963-67-4 6-benzyl-2-(2-furyl)-1(3)H-imidazo<4,5-c>-carbazole 
• 138963-65-2 6-benzyl-2-methoxycarbonylamino-1(3)H-imidazo<4,5-c>carbazole 
• 138963-61-8 3-amino-9-benzyl-4,6-dinitrocarbazole 
• 138963-57-2 9-benzyl-3-carbethoxyamino-4-nitro carbazole 
• 138963-58-3 3-carbethoxyamino-4,6-dinitro-9-benzylcarbazole 
• 1454710-77-0 C₃₇H₃₂N₂O₂S₂ 

Relevant articles and documents

Design, Synthesis and Discovery of N,N’-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure-based virtual screening approach using the ZIKV NS5-MTase. A novel series of molecules with a carbazoyl-aryl-urea structure has been discovered and a library of analogues has been synthesized. The new compounds inhibit ZIKV MTase with IC50 between 23–48 μM. In addition, carbazoyl-aryl-ureas also proved to inhibit ZIKV replication activity at micromolar concentration.

Carbazole N-substituent effect upon DTMA: Stabilizing and photochromic modulating

Dithienylmaleimide derivatives 7-27 were synthesized by introducing N-substituted carbazole for photo-stabilizing purpose, and the structures were fully confirmed. The photochromism and photo-stability were recorded via UV-vis spectra. Only ortho compounds 8-17 with N-substituents on carbazole moiety showed escalated photochromic change, while compound 7 and the para counterparts 18-27 showed no appreciable photochromism. Additionally, compounds 8-18 exhibited good photo-stability except 17 under 254 nm irradiation. The unstability of 17 may probably due to overrunning hindrance. These photochromic patterns indicated that hindrance and electronic effect mutually paid a decisive influence on the photochromism and photo-stability, which potentially exploited a new way to construct novel photochromic materials with regulable and conceivable performance.

Oxidative Pd(II)-catalyzed C-H bond amination to carbazole at ambient temperature

We report a new Pd(II)-catalyzed C-H bond amination reaction to form carbazoles, an important motif that is prevalent in a range of systems. The catalytic amination process operates under extremely mild conditions and produces carbazole products in good to excellent yields. Carbazoles possessing complex molecular architecture can also be formed using this reaction, highlighting its potential in natural product synthesis applications. Preliminary mechanistic investigations reveal the reaction proceeds through a Pd(II)/Pd(IV) manifold and that reductive elimination from a high oxidation state Pd(IV) complex facilitates the mild conditions of this transformation. Copyright

3-Aminocarbazole Compounds, Pharmaceutical Composition Containing the Same and Method for the Preparation Thereof

A compound of formula (I), in which R1, R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.

3-AMINOCARBAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR THE PREPARATION THEREOF

A compound of formula (I), in which R1 , R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.

N-Alkylation of 1H-indoles and 9H-carbazoles with alcohols

A comparative study of N-alkylation of 1H-indole and 9H-carbazole derivatives with alcohol derivatives was performed using classic Mitsunobu reaction conditions, i.e. DEAD/PPh3, azodicarboxamide derivatives such as TMAD in the presence of PBus

A new method of nitration of carbazoles using ceric ammonium nitrate (CAN)

A convenient procedure for the mononitration of carbazole and 9-alkylcarbazoles using CAN in CH3CN in presence of SiO2 is reported. The results with 9-acetyl, 9-benzoyl and 9- benzenesulphonylcarbazoles are also discussed.

Antiparasitic agents: Part XIV -- Synthesis of 2,6-disubstituted-1(3)H-imidazocarbazoles as anthelmintic agents

Substituted 9-benzyl/methylcarbazoles (2-17) and 6-benzyl/methyl-2-furyl/methoxycarbonylamino-1(3)H-imidazocarbazoles (18-21) have been synthesized and screened for their antifilarial, anthelminitic and antiamoebic activities against Litomosoides carini, Acanthocheilonema viteae, Acylostoma ceylanicum, Nippostrongylus brasiliensis, Hymenolepis nana and Entamoeba histolytica.No significant activity has been observed.