94136-64-8Relevant academic research and scientific papers
MDM2-HDAC double-target inhibitor, medicinal composition and preparation and application of MDM2-HDAC double-target inhibitor
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Paragraph 0126; 0137; 0138, (2018/12/14)
The invention provides a MDM2-HDAC double-target inhibitor, a medicinal composition and preparation and application of the MDM2-HDAC double-target inhibitor. The MDM2-HDAC double-target inhibitor hasa structure as shown in formula I. The inhibitor with th
Preparation of bifunctional isocyanate hydroxamate linkers: Synthesis of carbamate and urea tethered polyhydroxamic acid chelators
Fernando, Rasika,Shirley, Jonathan M.,Torres, Emilio,Jacobs, Hollie K.,Gopalan, Aravamudan S.
, p. 6367 - 6371,5 (2012/12/12)
Two novel bifunctional N-methylhydroxamate-isocyanate linkers 20 and 21 were prepared in good yield and high purity from the corresponding amine salts using a biphasic reaction with phosgene. The facile ring opening reaction of N-Boc lactams using the anion of O-benzylhydroxylamine gave the protected amino hydroxamates 6a and 6c in good yields. The selective methylation of the hydroxamate nitrogen in the presence of the N-Boc group in these intermediates could be readily accomplished. The utility of the linkers was clearly demonstrated by the synthesis of the carbamate-tethered trishydroxamic acid 27 and the urea-tethered 29.
HDAC INHIBITORS
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Page/Page column 27, (2009/04/25)
The present invention provides hydroxamic acid compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the hydroxamic acid compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of the present invention.
Synthesis of recyclable water-soluble polymeric chelators
Koshti, Nirmal,Naik, Shubhangi,Parab, Bharat
, p. 388 - 391 (2007/10/03)
Facile synthesis of water-soluble poly(N-isopropyl acrylamide) bound chelators is reported. These polymeric chelators have a lower critical solution temperature (LCST) and quantitatively phase-separate on heating. Their utility in metal removal and recycling is demonstrated with hydroxamic acid as ligand and Fe3+ as metal ion.
Artificial Siderophores. 1. Synthesis and Microbial Iron Transport Capabilities
Lee, Byung Hyun,Miller, Marvin J.,Prody, Catherine A.,Neilands, John B.
, p. 317 - 323 (2007/10/02)
Several di- and trihydroxamate analogues of natural microbial iron chelators have been prepared.The syntheses involved linkage of core structural units, including pyridinedicarboxylic acid, benzenetricarboxylic acid, nitrilotriacetic acid, and tricarballylic acid, by amide bonds to 1-amino-ω-(hydroxyamino)alkanes to provide the polyhydroxamates 1-5.The required protected (hydroxyamino)alkanes 8, 16, and 21 were prepared by different routes. 1-Amino-3-propane di-p-toluenesulfonate (8) was prepared from the N-protected aminopropanol 6 by oxidation to the aldehyde, formation of the substituted oxime, and reduction with NaBH3CN followed by deprotection of the Boc group.The pentyl derivatives 16 and 21 were made by direct alkylation with either benzyl acetohydroxamate or N-carbobenzoxy-O-benzylhydroxylamine.In Escherichia coli RW193 most of the analogues behaved nutritionally as ferrichrome.However, in E. coli AN193, a mutant lacking the ferrichrome receptor, capacity to use other natural siderophores was retained while response to all analogues was lost.
