94159-47-4

Usage

Uses

Used in Digestive Health Applications:
(3alpha,5beta,7alpha,12beta)-3-(3-carboxy-1-oxopropoxy)-7,12-dihydroxycholan-24-oic acid is used as a digestive aid for promoting the digestion and absorption of dietary fats and fat-soluble vitamins. Its emulsifying properties help break down fats into smaller droplets, increasing their surface area for lipase enzymes to act upon, thereby enhancing their absorption in the intestines.
Used in Cholesterol Homeostasis Regulation:
In the pharmaceutical industry, (3alpha,5beta,7alpha,12beta)-3-(3-carboxy-1-oxopropoxy)-7,12-dihydroxycholan-24-oic acid is used as a cholesterol-lowering agent. Its role as a signaling molecule helps regulate metabolic processes and maintain cholesterol homeostasis, making it a potential therapeutic candidate for managing hypercholesterolemia and related conditions.
Used in Drug Delivery Systems:
(3alpha,5beta,7alpha,12beta)-3-(3-carboxy-1-oxopropoxy)-7,12-dihydroxycholan-24-oic acid can be utilized in the development of drug delivery systems, particularly for hydrophobic drugs. Its ability to emulsify fats and interact with lipid-based formulations can improve the solubility, bioavailability, and targeted delivery of various therapeutic agents.
Used in Cosmetics and Personal Care Products:
In the cosmetics industry, (3alpha,5beta,7alpha,12beta)-3-(3-carboxy-1-oxopropoxy)-7,12-dihydroxycholan-24-oic acid may be used as an ingredient in skincare and hair care products. Its emulsifying and solubilizing properties can enhance the texture and efficacy of formulations, while its cholesterol-regulating effects may contribute to maintaining healthy skin and hair.

Upstream product

• 108-30-5 succinic acid anhydride 
• 81-25-4 cholic acid 

Relevant academic research and scientific papers

Preparation method of ursodesoxycholic acid

The invention discloses a preparation method of ursodesoxycholic acid. Cholic acid is adopted as a raw material, and the ursodesoxycholic acid is prepared through 3 alpha-hydroxyl selective protection, 7 alpha-hydroxyl selective oxidation, ester group protection, 12 alpha-hydroxyl methanesulfonic acid esterification, 3 and 24 site protecting group selective hydrolysis, eliminating and catalytic hydrogenation. According to the preparation method, the low-cost cholic acid is adopted as the raw material, a synthesizing method is novel, low in cost, high in yield and mild in reaction condition, operation is easy and convenient, environmental friendliness is achieved, and industrial production is convenient.

Method for preparing obeticholic acid, ursodeoxycholic acid and 7-ketolithocholicacid

The invention discloses a method for preparing obeticholic acid, 7-ketolithocholicacid and ursodeoxycholic acid. Cholic acid is used as a raw material for preparing obeticholic acid through selectiveprotection by a 3-alpha-hydroxyl group, selective oxidation of a 7-alpha-hydroxyl group, esterification of a 24th carboxyl group, methanesulfonation of a 12-alpha-hydroxyl group, elimination, hydrolysis, silylation, condensation, hydrolysis, catalytic hydrogenation, carbonyl reduction and other reactions; an intermediate is subjected to catalytic hydrogenation to prepare the 7-ketolithocholicacidand then is reduced to prepare the ursodeoxycholic acid. The method provided by the invention uses cheap cholic acid as the raw material, and has advantages of novel synthesis method, low cost, high yield, mild reaction condition, high simplicity in operation, environmental friendliness and high convenience in industrial production.

Method for synthesizing lithocholic acid from cholic acid

The invention discloses a method for synthesizing lithocholic acid from cholic acid. According to the method, cholic acid is used as a starting raw material, and lithocholic acid is synthesized through the following four steps of reaction: selective protection of 3alpha-OH; oxidation of 7alpha-OH and 12alpha-OH into carbonyl groups; hydrolysis; and Huang Min-lon reduction. The raw material used in the method is easily available and cheap, and the method is few in synthesis steps and side reactions, simple in after-treatment, high in overall yield and suitable for industrial production.

New biocompatible polyesters based on bile acids

New biocompatible and biodegradable polyesters based on cholic acid or deoxycholic acid were synthesized by polycondensation reaction of 3-succinoyloxy-derivatives of bile acids with diethylene glycol. Chemical structure of the synthesized compounds has been proved by their elemental analysis, 1H-, 13C-NMR and IR spectra. Thermal behaviour and cristallinity of the polymers have been investigated.