941676-44-4

Basic information

• Product Name: ethyl 3-((S)-5-oxo-1-(pent-4-enyl)pyrrolidin-2-yl)but-3-enoate
• Synonyms: ethyl 3-((S)-5-oxo-1-(pent-4-enyl)pyrrolidin-2-yl)but-3-enoate
• CAS NO: 941676-44-4
• Molecular Weight: 265.353
• Mol File: 941676-44-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-((S)-5-oxo-1-(pent-4-enyl)pyrrolidin-2-yl)but-3-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-((S)-5-oxo-1-(pent-4-enyl)pyrrolidin-2-yl)but-3-enoate(941676-44-4)
• EPA Substance Registry System: ethyl 3-((S)-5-oxo-1-(pent-4-enyl)pyrrolidin-2-yl)but-3-enoate(941676-44-4)

Safety Data

• Hazardous Substances Data: 941676-44-4(Hazardous Substances Data)

Upstream product

• 941676-33-1 (S)-5-(1-iodovinyl)-1-(pent-4-enyl)pyrrolidin-2-one 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 

Downstream Products

• 794528-61-3 (1S,3aR,10aS,10bR)-1-methyloctahydro-2H-furo[3,2-c]pyrrolo[1,2-a]azepine-2,8(1H)-dione 

Relevant articles and documents

Total synthesis of (-)-stemoamide

(Chemical Equation Presented) A stereocontrolled total synthesis of (-)-stemoamide (1) is presented. The synthesis starts from commercially available (S)-pyroglutaminol (4). A chemoselective iodoboration of 5 was used to access key intermediate 3. The β,γ-unsaturated azepine derivative 2 was obtained via a Pd(0)-catalyzed sp2-sp3 Negishi cross-coupling using a Reformatsky nucleophile followed by a ring-closing metathesis reaction. The required C8-C9 trans-stereochemistry of 1 was accessed through a stereoselective bromolactonization/1,4-reduction sequence.