941694-72-0Relevant academic research and scientific papers
Rearranging the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve binding recognition by kinases
Marquez, Victor E.,Comin, Maria J.
, p. 585 - 588 (2007)
A novel bicyclo[3.1.0]hexane carbocyclic nucleoside (4) with a south-like conformation amenable to interact with the herpes thymidine kinase (HSV-tk) was synthesized with an endo-hydroxyl group positioned at the tip of the bicyclo[3.1.0]hexane ring system
Sculpting the bicyclo[3.1.0]hexane template of carbocyclic nucleosides to improve recognition by herpes thymidine kinase
Comin, Maria J.,Agbaria, Riad,Ben-Kasus, Tsipi,Huleihel, Mahmoud,Liao, Chenzhong,Sun, Guangyu,Nicklaus, Marc C.,Deschamps, Jeffrey R.,Parrish, Damon A.,Marquez, Victor E.
, p. 6216 - 6222 (2008/02/03)
The replacement of the furanose ring by a cyclopentane in nucleosides generates a group of analogues known generically as carbocyclic nucleosides. These compounds have increased chemical and enzymatic stability due to the absence of a true glycosyl bond t
