941715-72-6Relevant articles and documents
Design and Synthesis of a Highly Selective and in Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins
Preston, Alex,Atkinson, Stephen,Bamborough, Paul,Chung, Chun-Wa,Craggs, Peter D.,Gordon, Laurie,Grandi, Paola,Gray, James R. J.,Jones, Emma J.,Lindon, Matthew,Michon, Anne-Marie,Mitchell, Darren J.,Prinjha, Rab K.,Rianjongdee, Francesco,Rioja, Inmaculada,Seal, Jonathan,Taylor, Simon,Wall, Ian,Watson, Robert J.,Woolven, James,Demont, Emmanuel H
, p. 9070 - 9092 (2020/10/19)
Pan-bromodomain and extra terminal domain (BET) inhibitors interact equipotently with the eight bromodomains of the BET family of proteins and have shown profound efficacy in a number of in vitro phenotypic assays and in vivo pre-clinical models in inflam
Facile synthesis of benzamides to mimic an α-helix
Ahn, Jung-Mo,Han, Sun-Young
, p. 3543 - 3547 (2008/02/06)
A new α-helix mimetic was designed by using a benzamide as a rigid scaffold. It presents three functional groups corresponding to side chains of amino acids found at the i, i + 4, and i + 7 positions of an ideal α-helix, which are displayed on the same he
