94192-18-4

Usage

Uses

Used in Pharmaceutical Industry:
3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanoic acid is used as an anti-inflammatory and analgesic agent for its potential to alleviate pain and reduce inflammation. Its unique chemical structure, including the 1,2,4-oxadiazol ring and the 4-methoxyphenyl group, may contribute to its biological activities and therapeutic effects.
Used in Research Applications:
3-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanoic acid is used as a research compound to study its potential biological activities and effects. Further studies are warranted to fully understand its potential applications and to explore its use in drug development for various therapeutic areas.

InChI:InChI=1/C12H12N2O4/c1-17-9-4-2-8(3-5-9)12-13-10(18-14-12)6-7-11(15)16/h2-5H,6-7H2,1H3,(H,15,16)

Upstream product

• 108-30-5 succinic acid anhydride 
• 5373-87-5 4-methoxybenzamidoxime 
• 155500-83-7 C₁₃H₁₄N₂O₄ 
• 874-90-8 4-methoxybenzonitrile 
• 3717-22-4 (Z)-para-methoxybenzaldehyde oxime 

Relevant academic research and scientific papers

Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety

An efficient and mild one-pot protocol has been developed for the synthesis of 1,2,4-oxadiazoles via the reaction of amidoximes with dicarboxylic acid anhydrides in a NaOH/DMSO medium. The method allows the synthesis of diversely substituted carboxylic acids bearing the 1,2,4-oxadiazole motif, – a popular building block for pharmaceutical research, in moderate to excellent yields. The reaction scope includes aromatic and heteroaromatic amidoximes as well as five-, six- and seven-membered anhydrides. The advantages of this procedure are proven gram-scalability and the use of inexpensive starting materials, which from a process chemistry point of view are essential for future industrial applications.

NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND

The present invention provides a compound having excellent regulating action on blood lipid level. The present invention provides a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, etc., wherein A represents a 5-membered nitrogen-containing aromatic heterocyclyl group; R1 represents COOH or the like; each R2 represents an alkyl or the like; each R3 represents an optionally substituted phenyl, an optionally substituted phenylalkyl, or the like; m represents 0, 1, 2, or 3; n represents 0 or 1; each of R4, R5, R6, and R7 represents H, an alkyl, or the like; and B represents an optionally substituted naphthyl, an optionally substituted aromatic heterocyclyl, or a group represented by the following formula (II) wherein each of B1 and B2 represents an optionally substituted phenyl or an optionally substituted aromatic heterocyclyl.

Synthesis, characterization, and antimicrobial activities of clubbed [1,2,4]-oxadiazoles with fluorobenzimidazoles

(Chemical Equation Presented) In this study, a novel series of substituted 4,6-difluoro-2-{2-[3-(substituted-phenyl)-[1,2,4]-oxadiazol-5-yl]-ethyl} -1H-benzo[d]imidazole derivatives were synthesized by condensation of 2,4-difluoro-6-nitrophenyl amine with 3-(substitutedphenyl-[1,2,4]-oxadiazol- 5yl) propionic acid by using 2,4,6-trichlorobenzoyl chloride in the presence of triethyl amine base. The compounds were evaluated for their preliminary in vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Salmonella typhosa. The antibacterial data of the tested compounds indicated that most of the synthesized compounds showed moderate activity with reference standard Gentamycin.

Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence

(Chemical Equation Presented) A general method for the synthesis of bis-substituted 1,2,4-oxadiazoles from readily available arylnitriles and activated carbonyls in a single continuous microreactor sequence is described. The synthesis incorporates three s

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor

Biaryl anthranilides are reported as potent and selective full agonists for the high affinity niacin receptor GPR109A. The SAR presented outlines approaches to reduce serum shift and both CYPCYP2C8 and CYP2C9 liabilities, while improving PK and maintainin

A handy and solventless direct route to primary 3-[3-aryl-1,2,4-oxadiazol- 5-yl]propionamides using microwave irradiation

A one-step, simple and straightforward synthesis of the title amides from the corresponding carboxylic acids, urea and imidazole under microwave irradiation is described.