94192-26-4Relevant academic research and scientific papers
Fabrication of chitosan-bis (4-formyl-2 methoxy phenyl carbonate) Schiff base nanoparticles and evaluation of their antioxidant and anticancer properties
Thyriyalakshmi,Radha
, (2019)
Abstract: The present study details on the mechanism of synthesis of bis (4-formyl-2 methoxy phenyl carbonate), using two green reagents dimethyl carbonate and vanillin for application as therapeutic agent. The synthesized FMPC was identified from the 13C nuclear magnetic resonance spectra. The novel modified Schiff base nanoparticles resulted from the crosslinking of FMPC with chitosan were confirmed by cross-polarization magic angle spinning carbon-13 nuclear magnetic resonance spectroscopy. The incorporation of the FMPC was identified from the amorphous X-ray diffraction patterns of C-FMPC-Nps. The thermal stability of the formed nanoparticles was predicted using thermogravimetric analysis. The morphology of the nanoparticles as observed from HRTEM was found to be smooth and spherical in nature. Both FMPC and C-FMPC-Nps showed significant radical scavenging potential and anticancer property. The carbonate ester backbone and the moiety present in chitosan-FMPC-nanoparticles, underwent hydrolysis at the targeted cancer causing microenvironment to release vanillin and chitosan and enhance the anticancer activity. Both FMPC and C-FMPC-Nps exhibits a dose dependent cytotoxicity towards the different cell lines and it was tested with a commercial drug for application studies. Graphical abstract: Effective synthesis of FMPC, successful incorporation onto chitosan nanoparticles for the formation of C-FMPC-Nps. The formed Schiff base compound proves to have enhanced antioxidant and anticancer efficacy.[Figure not available: see fulltext.].
Vanillin derived a carbonate dialdehyde and a carbonate diol: novel platform monomers for sustainable polymers synthesis
Bai, De,Chen, Qin,Chai, Yang,Ren, Tianhua,Huang, Caijuan,Ingram,North, Michael,Zheng, Qiang,Xie, Haibo
, p. 34297 - 34303 (2018)
Vanillin has been regarded as one of the important biomass-based platform chemicals for aromatic polymers synthesis. Herein, novel symmetric bis(4-formyl-2-methoxyphenyl)carbonate (BFMC) and bis(4-(hydroxymethyl)-2-methoxyphenyl)carbonate (BHMC) polymeric monomers have been synthesized in high yields using vanillin as a raw chemical, which have been submitted for polymer synthesis via well-established polymeric strategies. A new class of poly(carbonate ester)s oligomers with amide moieties in their side chain can be prepared by using the BFMC as one of monomers via the Passerini three compound reaction (3CR). A new class of poly(carbonate ester)s oligomers and poly(carbonate urethane)s can be prepared via reactions between BHMC with dicarboxylic acid chlorides and diisocyanates, respectively. Their structure have been confirmed by 1H NMR, 13C NMR and FTIR, and the gel permeation chromatograph (GPC) analysis shows that the Mn of poly(carbonate ester)s oligomers ranges from 3100 to 7900 with PDI between 1.31 and 1.65, and the Mn of poly(carbonate urethane)s ranges from 16?400 to 24?400 with PDI ranging from 1.36 to 2.17. The DSC analysis shows that the poly(carbonate ester)s oligomers have relative low Tg ranging from 37.4 to 74.1 °C, and the poly(carbonate urethane)s have Tg ranging from 97.3 to 138.3 °C, mainly correlating to the structure of dicarboxylic acid chlorides and diisocyanates used.
Thiol-Ene Networks from Sequence-Defined Polyurethane Macromers
Alabi, Christopher A.,De Hoe, Guilhem X.,Hillmyer, Marc A.,Hoff, Emily A.,Mulvaney, Christopher M.
supporting information, p. 6729 - 6736 (2020/04/30)
To date, scalability limitations have hindered the exploration and application of sequence-defined polymers in areas such as synthetic plastics, fibers, rubbers, coatings, and composites. Additionally, the impact of sequence on the properties of cross-lin
Bio-based diol polymerizable monomer containing carbonate ester structure as well as preparation method and application thereof
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Paragraph 0022, (2018/07/30)
The invention provides a bio-based diol polymerizable monomer containing a carbonate ester structure as well as a preparation method and application thereof. A structural formula of the bio-based diolpolymerizable monomer is as follows: the formula is shown in the description, wherein R and R1 are hydrogen or methoxyl. The preparation method of the bio-based diol polymerizable monomer comprises the following steps: taking one bio-based monomer of vanillin, syringaldehyde and p-hydroxybenzaldehyde as a raw material to react with triphosgene under the action of a catalyst; recrystallizing a reaction product to obtain a bio-based dialdehyde monomer containing the carbonate ester structure; then taking the dialdehyde monomer as a raw material to react with sodium borohydride; carrying out recrystallization or column-passing separation on a reaction product to obtain the bio-based polymerizable diol polymerizable monomer containing the carbonate ester structure. The diol polymerizable monomer provided by the invention can be used for preparing polyester and polyurethane, and inflammable and explosive volatile matters with a low boiling point are not generated, so that the bio-based diol polymerizable monomer has green and environment-friendly performance, is environmentally friendly and also is a low price and better performance; the preparation method is simple and easy for production.
Reaction of Glyceraldehyde With Aryl and Alkyl Chloroformates
Podraza, Kenneth F.
, p. 1197 - 1199 (2007/10/02)
A number of 2,5-bis(aryl- and alkyloxycarbonyloxymethylene)-3,6-bis(aryl- and alkoxycarbonyloxy)-1,4-dioxanes 5a-d have been prepared by the reaction of glyceraldehyde with aryl and alkyl chloroformates.Bis aryl carbonates were also formed under certain c
