942049-14-1Relevant articles and documents
Formal synthesis of the ACE inhibitor benazepril·HCl via an asymmetric aza-Michael reaction
Yu, Luo-Ting,Huang, Ji-Ling,Chang, Ching-Yao,Yang, Teng-Kuei
, p. 641 - 648 (2006)
A formal enantioselective synthesis of benazepril·HCl (4), an antihypertensive drug, is reported. Our synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester (LHPE, 1) to 4-(2-nitrophenyl)-4-oxo-but-2-enoic acid methyl est