942057-59-2

Upstream product

• 108-90-7 chlorobenzene 
• 40587-07-3 1-(4-bromophenyl)-2-(methylamino)ethanol 
• 885595-75-5 tert-butyl 2-(4-bromophenyl)-2-(4-chlorophenyl)ethyl(methyl)carbamate 
• 857531-36-3 2-(4-bromophenyl)-2-(4-chlorophenyl)-N-methylethanamine 
• 885595-50-6 (2-(4-bromophenyl)-2-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl)-methyl-carbamic acid tert-butyl ester 
• 7306-68-5 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 

Relevant academic research and scientific papers

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design

6-Phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein.