94220-45-8

Basic information

• Product Name: 5-Chloro-1H-pyrazolo[4,3-b]pyridine
• Synonyms: 5-CHLORO-1H-PYRAZOLO[4,3-B]PYRIDINE;1H-Pyrazolo[4,3-b]pyridine,5-chloro-;5-chloro-1H-pyrazolo[4;5-Chloro-1H-pyrazolo[4,3-...
• CAS NO: 94220-45-8
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.57
• Product Categories: Heterocycle-Pyridine series
• Mol File: 94220-45-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 323.8 °C at 760 mmHg
• Flash Point: 179.3 °C
• Appearance: /
• Density: 1.531 g/cm³
• Vapor Pressure: 0.000485mmHg at 25°C
• Refractive Index: 1.72
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.74±0.40(Predicted)
• CAS DataBase Reference: 5-Chloro-1H-pyrazolo[4,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1H-pyrazolo[4,3-b]pyridine(94220-45-8)
• EPA Substance Registry System: 5-Chloro-1H-pyrazolo[4,3-b]pyridine(94220-45-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 94220-45-8(Hazardous Substances Data)

Usage

Uses

5-Chloro-1H-pyrazolo[4,3-b]pyridine is an intermediate used to prepare 2-aryl or heteroaryl indole derivatives as ASIC channel modulators for treating pain, bone diseases, and other disorders.

InChI:InChI=1/C6H4ClN3/c7-6-2-1-4-5(9-6)3-8-10-4/h1-3H,(H,8,10)

Upstream product

• 164666-68-6 3-amino-6-chloro-2-methylpyridine 

Downstream Products

• 1357945-27-7 5-chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine 

Relevant articles and documents

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The invention provides a neurotrophic factor tyrosine kinase receptor inhibitor. The tyrosine kinase receptor inhibitor provided by the invention has a tricyclic parent core structure, can inhibit theactivity of Trk kinase and can be used for treating mammalian diseases mediated by the Trk kinase.