942218-71-5

Upstream product

• 942218-74-8 C₄₁H₄₁N₃O₁₂ 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 942218-72-6 C₂₄H₂₇N₃O₁₂ 
• 942218-73-7 C₂₀H₂₃N₃O₁₀ 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 6979-97-1 3',5'-diacetylthymidine 
• 50-89-5 thymidine 

Relevant academic research and scientific papers

Caged nucleotides and oligonucleotides and their application

There is disclosed nucleotides and nucleotide analogs having a protecting or “caging” group. There is further disclosed oligonucleotides and oligonucleotides analogs formed having a protecting or “caging” group. There is further disclosed a method for decaging the nucleotides and nucleotide analogs having a protecting or “caging” group and oligonucleotides and oligonucleotide analogs having a caging group.

Photochemical DNA activation

A new photocaged nucleoside was synthesized and incorporated into DNA with the use of standard synthesis conditions. This approach enabled the disruption of specific H-bonds and allowed for the analysis of their contribution to the activity of a DNAzyme. Brief Irradiation with nonphotodamaging UV light led to rapid decaging and almost quantitative restoration of DNAzyme activity. The developed strategy has the potential to find widespread application in the light-induced regulation of oligonucleotide function.