94224-71-2Relevant academic research and scientific papers
RhIII-Catalyzed Regioselective Preparation of 3-Hetero-Substituted Isocoumarins from Aryl Carboxylic Acids and Alkynes
Song, Lijuan,Xiao, Jing,Dong, Wanrong,Peng, Zhihong,An, Delie
, p. 341 - 349 (2017)
An oxygen-mediated annulation reaction has been reported herein. Various 3-hetero-substituted isocoumarins were successfully prepared with high efficiency (yields up to 88 %) and good functional-group tolerance (35 examples) in the presence of a rhodium catalyst. A plausible mechanism has also been proposed that shows the high regioselectivity mostly likely originates from the electron-density difference between the alkynyl carbon atoms of the substrate.
Chlorosulfonic acid-mediated cyclization of 4-phenyl-3-isocoumarincarboxylic acids and 4-phenyl-3-isoquinolinonecarboxylic acids: an efficient synthesis of 3-oxoindeno[2,1-c]isocoumarins and 3-oxoindeno[2,1-c]isoquinolinones
Jagtap, Prakash G.,Chen, Zhiyu,Southan, Garry J.
scheme or table, p. 2057 - 2059 (2009/09/06)
A highly efficient and clean method has been developed for the synthesis of 3-oxoindeno[2,1-c]isocoumarins and 3-oxoindeno[2,1-c]isoquinolinones from 4-phenyl-3-isocoumarincarboxylic acids and 4-phenyl-3-isoquinolinonecarboxylic acids, respectively.
Tetracyclic benzamide derivatives and methods of use thereof
-
Page 26; 44, (2010/02/09)
The invention relates to Tetracyclic Benzamide Derivatives; compositions comprising a Tetracyclic Benzamide Derivative; and methods for treating or preventing an inflammatory disease, a reperfusion disease, an ischemic condition, renal failure, diabetes,
Construction of heterocyclic compounds by use of α-diazophosphonates: New one-pot syntheses of indoles and isocoumarins
Nakamura, Yoshinori,Ukita, Tatsuzo
, p. 2317 - 2320 (2007/10/03)
(Matrix Presented) α-Diazophosphonates, which have extremely useful properties from a synthetic point of view, are disclosed as 1,1-ambiphilic one-carbon building blocks for one-pot construction of various heterocyclic compounds. They are easily prepared and have higher stability by the effect of the phosphoryl group than corresponding α-diazocarbonyl compounds. Using this synthon, we have developed a novel, mild, and efficient synthetic method of 2,3-disubstituted indoles and 3,4-disubstituted isocoumarins.
UNE SYNTHESE ORIGINALE ET INATTENDUE D'ISOCOUMARINES FONCTIONNELLES
Babin, P.,Dunogues, J.
, p. 4389 - 4392 (2007/10/02)
Reaction of Ph3P=CH-COOEt with ortho benzoyl benzoic acid derivates offers an easy and surprising entry to functional isocoumarins via the thermal decomposition of the keto-ylide intermediates or by subsequent oxidation of the expected indenones.
