942291-68-1Relevant academic research and scientific papers
Thalidomide analogs from diamines: Synthesis and evaluation as inhibitors of TNF-α production
De Almeida, Mauro Vieira,Teixeira, Francisco Martins,De Souza, Marcus Vinicius Nora,Amarante, Giovanni Wilson,Alves, Caio Cesar De Souza,Cardoso, Silvia Helena,Mattos, Ana Marcia,Ferreira, Ana Paula,Teixeira, Henrique Couto
, p. 223 - 226 (2007)
Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83-94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-α production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.
