94236-26-7Relevant academic research and scientific papers
Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells
Cai, Bo,Kim, Dongwook,Akhand, Saeed,Sun, Yixing,Cassell, Robert J.,Alpsoy, Aktan,Dykhuizen, Emily C.,Van Rijn, Richard M.,Wendt, Michael K.,Krusemark, Casey J.
, p. 17057 - 17061 (2019)
We report the selection of DNA-encoded small molecule libraries against protein targets within the cytosol and on the surface of live cells. The approach relies on generation of a covalent linkage of the DNA to protein targets by affinity labeling. This c
MEANS AND METHODS FOR BIOLUMINESCENCE RESONANCE ENERGY TRANSFER (BRET) ANALYSIS IN A BIOLOGICAL SAMPLE
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Paragraph 0023, (2016/06/21)
The invention relates to the field of in vitro detection methods using luminescence. Provided is a sensor molecule for detecting an analyte of interest in a sample using bioluminescence resonance energy transfer (BRET), the sensor molecule comprising a pr
Receptor-based design of dihydrofolate reductase inhibitors: Comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues
Kuyper,Roth,Baccanari,Ferone,Beddell,Champness,Stammers,Dann,Norrington,Baker
, p. 303 - 310 (2007/10/02)
By the use of molecular models of Escherichia coli dihydrofolate reductase (DHFR), analogues of trimethoprim (TMP) were designed which incorporated various 3'-carboxyalkoxy moieties in order to acquire ionic interactions with positively charged active-sit
