94238-14-9

Upstream product

• 94223-53-7 4-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-butan-2-one 
• 22815-98-1 2-(4-chlorophenyl)-5-methyl-1,3,4-oxadiazole 

Downstream Products

• 94223-64-0 3-(4-Chloro-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole 
• 94223-68-4 2-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-cyclohexylamine 
• 94223-57-1 2-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-cyclohexanone 
• 94223-72-0 (4aR,8aR)-3-(4-Chloro-phenyl)-5,6,7,8,8a,9-hexahydro-4aH-[1,2,4]triazolo[4,3-a]indole 
• 94223-72-0 (4aR,8aS)-3-(4-Chloro-phenyl)-5,6,7,8,8a,9-hexahydro-4aH-[1,2,4]triazolo[4,3-a]indole 

Relevant academic research and scientific papers

SYNTHESIS OF CYCLOPENTANO-s-TRIAZOLES BY THE INTRAMOLECULAR RING TRANSFORMATION OF 1,3,4-OXADIAZOLES

Cyclopentano-s-triazoles were synthesized by intramolecular ring transformation starting from γ-keto-1,3,4-oxadiazoles 5 and 9.The required functionality for this intramolecular reaction was established by (i) the reaction of lithiated 2-methyl-1,3,4-oxadiazole 4 with the methyl enol ether of α-bromo ketones followed by hydrolysis; (ii) reductive amination of γ-ketones 5 and 9 to further reorganized hydrazide 7 and γ-amino-1,3,4-oxadiazole 9 with NaBH3CN; and (iii) pyrolysis of 7 and 9 at 280 deg C (5 mmHg) to the cyclopentano-s-triazoles 8 and 11.By the same treatment, the S-connected analogue 2 afforded the desired fused s-triazole 17.