22815-98-1

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(4-chlorophenyl)-5-methyl-1,3,4-oxadiazole is used as an intermediate or building block in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Agrochemical Production:
In the agrochemical industry, 2-(4-chlorophenyl)-5-methyl-1,3,4-oxadiazole serves as a key intermediate in the production of various agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications.
Used in Materials Science:
2-(4-chlorophenyl)-5-methyl-1,3,4-oxadiazole is utilized in materials science for the development of new materials with specific properties. Its unique chemical structure contributes to the creation of materials with tailored characteristics for various applications.
Used in Organic Electronics and Optoelectronics:
CPMD is used in the field of organic electronics and optoelectronics due to its charge transport properties. It is employed in the development of devices such as organic light-emitting diodes (OLEDs) and organic solar cells, where its properties can improve the performance and efficiency of these technologies.
Used in Antimicrobial Applications:
2-(4-chlorophenyl)-5-methyl-1,3,4-oxadiazole is used as an antimicrobial agent in various applications. Its potential to inhibit the growth of microorganisms makes it a valuable component in products designed to combat microbial contamination.
Used in Antifungal Applications:
In antifungal applications, 2-(4-chlorophenyl)-5-methyl-1,3,4-oxadiazole is employed to prevent the growth of fungi. Its incorporation into antifungal products can help protect against fungal infections and contamination.
Used in Antitumor Research:
CPMD is used in antitumor research for its potential to inhibit tumor growth. Its biological activities are being studied for the development of new cancer treatments and therapies.

Upstream product

• 78-39-7 Triethyl orthoacetate 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 127-19-5 N,N-dimethyl acetamide 
• 26090-73-3 p-Chlorbenzaldehyd-acethydrazon 
• 16687-61-9 5-(4-chlorophenyl)-1H-tetrazole 
• 108-24-7 acetic anhydride 
• 22815-97-0 N’-acetyl-4-chlorobenzohydrazide 

Downstream Products

• 94223-53-7 4-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-butan-2-one 
• 94223-64-0 3-(4-Chloro-phenyl)-5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole 
• 94238-14-9 4-Chloro-benzoic acid N'-(5-methyl-4,5-dihydro-3H-pyrrol-2-yl)-hydrazide 
• 94223-68-4 2-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-cyclohexylamine 
• 94223-57-1 2-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-cyclohexanone 
• 94223-72-0 (4aR,8aR)-3-(4-Chloro-phenyl)-5,6,7,8,8a,9-hexahydro-4aH-[1,2,4]triazolo[4,3-a]indole 
• 94223-72-0 (4aR,8aS)-3-(4-Chloro-phenyl)-5,6,7,8,8a,9-hexahydro-4aH-[1,2,4]triazolo[4,3-a]indole 
• 876616-90-9 2-{5-methyl-2-[4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-yl]-oxazol-4-yl}-ethanol 

Relevant academic research and scientific papers

TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.

One-pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides

Convenient and efficient one pot method for the synthesis of 2,5-disubstituted-1,3,4-oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides has been developed. The methodology is applied to a wide range of difference aryl hydrazide and difference N,N-dimethyl amides to 2,5-disubstituted-1,3,4-oxadiazoles yield the in good to excellent yields. It will be possible wide useful application in synthesis. Synopsis Convenient and efficient one pot method for the synthesis of 2,5-disubstituted-1,3,4- oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides has been developed. The methodology is applied to a wide range of difference aryl hydrazide and difference N,N-dimethyl amides to 2,5-disubstituted- 1,3,4-oxadiazoles yield the in good to excellent yields. It will be possible wide useful application in synthesis. Copyright

Iodine-catalysed oxidative cyclisation of acylhydrazones to 2,5-substituted 1,3,4-oxadiazoles

An environmentally benign synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed starting from N-aroylhydrazones and N-acetylhydrazones at room or ambient temperature using a catalytic quantity of iodine in the presence of an aqueous hydrogen peroxide oxidant.

Efficient synthesis of 1,3,4-oxadiazoles promoted by NH4Cl

An efficient and inexpensive approach to the synthesis of 2-substituted and 2,5-disubstituted 1,3,4-oxadiazoles from arylhydrazides and orthoesters is reported using catalytic NH4Cl. The conditions are mild, and thus, compatible with a variety of functional groups. The optimized reaction is performed using 30 mol % of NH4Cl in 100% EtOH and is generally complete within 1 h for non-aromatic orthoesters and 2-10 h for aromatic orthoesters. The reaction permits both electron-releasing and electron-withdrawing groups on the arylhydrazide substrate. Most products are formed in high yields and require only minimal purification. Compared with earlier reports, the current reactions proceed in shorter time and require less of the orthoester.

High-temperature continuous flow synthesis of 1,3,4-oxadiazoles via N-acylation of 5-substituted tetrazoles

Applying continuous flow processing in a high-temperature/high-pressure regime (200-220 °C, 11-14 bar) 2,5-disubstituted-1,3,4-oxadiazoles are prepared in high yields within 5-10 min residence time by treatment of 5-substituted-1H-tetrazoles with anhydrides or acid chlorides as electrophiles (Huisgen reaction).

Silica sulfuric acid: An efficient and versatile acidic catalyst for the rapid and ecofriendly synthesis of 1,3,4-oxadiazoles at ambient temperature

A rapid and green synthesis of 2,5-disubstituted 1,3,4-oxadiazoles is reported. The title compounds were prepared by the reaction of different acyl hydrazides and orthoesters in the presence of silica sulfuric acid under solvent-free conditions. In this new process, reactions were run at ambient temperature and completed in a short period of time with high yields. Copyright Taylor & Francis Group, LLC.

Alum (KAl(SO4)2 ? 12H2O): An efficient and inexpensive catalyst for the one-pot synthesis of 1,3,4-oxadiazoles under solvent-free conditions

Alum (KAl(SO4)2 ? 12H2O) catalyzed the efficient synthesis of mono- and disubstituted 1,3,4-oxadiazoles by the condensation of acyl hydrazides with orthoesters under solvent-free conditions at 100°C. This methodology offers significant improvements for the synthesis of oxadiazoles with regard to the yield of products, simplicity in operation, inexpensive reagents, and green aspects by avoiding toxic catalysts and solvents.

DISILYLATED COMPOUNDS AS PRECURSORS OF HETEROCYCLES: A NEW AND EASY OXADIAZOLE SYNTHESIS

Silyl diacylhydrazines have been synthesized.When they are treated with a slight amount of a variety of catalyst (nucleophiles, F-, true or Lewis acids, Pd, Pt...), 1,3,4-oxadiazoles are obtained.This cyclization can be performed in one step by

ACID CATALYZED CYCLIZATION OF BIS SILYL DIACYLHYDRAZINES : A NEW 1,3,4-OXADIAZOLE SYNTHESIS

Diacylhydrazines are converted in good yields into 1,3,4-oxadiazoles with dichlorodimethylsilane and trifluoromethane sulfonic acid.