94242-53-2

Basic information

• Product Name: 8-fluorociprofloxacin
• Synonyms: 8-fluorociprofloxacin;3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
• CAS NO: 94242-53-2
• Molecular Formula: C₁₇H₁₇F₂N₃O₃
• Molecular Weight: 349.335
• Mol File: 94242-53-2.mol

Chemical Properties

• Boiling Point: 569.8°Cat760mmHg
• Flash Point: 298.4°C
• Appearance: /
• Density: 1.512g/cm³
• Vapor Pressure: 8.05E-14mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: 8-fluorociprofloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: 8-fluorociprofloxacin(94242-53-2)
• EPA Substance Registry System: 8-fluorociprofloxacin(94242-53-2)

Safety Data

• Hazardous Substances Data: 94242-53-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H17F2N3O3/c18-12-7-10-14(13(19)15(12)21-5-3-20-4-6-21)22(9-1-2-9)8-11(16(10)23)17(24)25/h7-9,20H,1-6H2,(H,24,25)

Upstream product

• 110-85-0 piperazine 
• 94695-52-0 1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinolin-3-carboxylic acid 

Downstream Products

• 112811-57-1 8-methoxyciprofloxacin 
• 94695-46-2 7-[4-(2-benzyloxycarbonyl-ethyl)-piperazin-1-yl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 158437-39-9 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-[4-(4-acetamidobenzenesulfonyl)-1-piperazinyl]-3-quinoline-carboxylic acid 

Relevant articles and documents

Cephalosporin derivatives

Cephalosporin derivatives of the general formula in which R represents one of the groups and the corresponding readily hydrolyzable, pharmaceutically acceptable esters and the pharmaceutically acceptable salts and hydrates of these compounds as well as a process for their manufacture and pharmaceutical preparations which contain these compounds, furthermore the use of the compounds in the control of illnesses and for the manufacture of the aforementioned preparations.

Quinolone Antibacterial Agents. Synthesis and Structure-Activity Relationships of 8-Substituted Quinoline-3-carboxylic Acids and 1,8-Naphthyridine-3-carboxylic Acids

A series of 7,8-disubstituted 1-cyclopropyl-6-fluoroquinoline-3-carboxylic acids, 7-substituted 1-cyclopropyl-6-fluoro-1,8-naphthyridine-3-carboxylic acids, and 10-substituted 9-fluoropyridobenzoxazine-6-carboxylic acids has been prepared and evaluated for antibacterial activity.The side chains examined at the 7-position (benzoxazine 10-position) included piperazinyl (g), 3-aminopyrrolidinyl (a), 3-(aminomethyl)pyrrolidinyl (b), and alkylated 3-(aminomethyl)pyrrolidinyl (c-f).Variations ta C-8 of the quinolone ring system included hydrogen, nitro, amino, fluorine and chlorine.The relative enhancement of in vitro activities by the side chains on the 8-hydrogen quinolone and 1,8-naphthyridine against Gram-negative organisms was a > b > g > c-f.The activity imparted to the substituted quinolone nucleus by the 8-substituent was in the order F > Cl > naphthyridine > H > benzoxazine > NH2 > NO2.These trends were retained in vivo.

1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines

1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and their esters, which are useful as intermediates for the preparation of compounds which are useful as anti-bacterial agents.