942420-07-7Relevant academic research and scientific papers
Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode
Inagaki, Hiroaki,Tsuruoka, Hiroyuki,Hornsby, Michael,Lesley, Scott A.,Spraggon, Glen,Ellman, Jonathan A.
, p. 2693 - 2699 (2008/02/07)
The substrate activity screening (SAS) method, a substrate-based fragment identification and optimization method for the development of enzyme inhibitors, was previously applied to cathepsin S to obtain a novel (2-arylphenoxy) acetaldehyde inhibitor, 2, w
