942589-70-0

Upstream product

• 13466-38-1 5-bromopyridin-2-ol 
• 381233-75-6 5-bromo-2-hydroxy-3-iodopyridine 
• 1066-54-2 trimethylsilylacetylene 
• 381233-75-6 5-bromo-3-iodo-1,2-dihydropyridin-2-one 

Downstream Products

• 220957-39-1 5-bromofuro<2,3-b>pyridine 
• 1251728-93-4 5-bromo-2-(trimethylsilyl)thieno[2,3-b]pyridine 

Relevant academic research and scientific papers

PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS

The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS

The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.

ANTIVIRAL 2-CARBOXY-THIOPHENE COMPOUNDS

Anti-viral agents of compounds of Formula (I) : wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.