381233-75-6

Basic information

• Product Name: 5-BROMO-3-IODO-PYRIDIN-2-OL
• Synonyms: 5-Bromo-2-hydroxy-3-iodopyridine;2(1H)-Pyridinone, 5-broMo-3-iodo-;5-BroMo-3-iodo-1H-pyridin-2-one;5-BroMo-3-iodo-2-hydroxypyridine, 97%;5-BroMo-3-iodopyridin-2(1H)-one;5‐bromo‐3‐iodo‐1,2‐dihydropyridin‐2‐one
• CAS NO: 381233-75-6
• Molecular Formula: C₅H₃BrINO
• Molecular Weight: 299.9
• Mol File: 381233-75-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 226-227℃
• Boiling Point: 316.3°Cat760mmHg
• Flash Point: 145.1°C
• Appearance: /
• Density: 2.512g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.714
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.52±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-BROMO-3-IODO-PYRIDIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-IODO-PYRIDIN-2-OL(381233-75-6)
• EPA Substance Registry System: 5-BROMO-3-IODO-PYRIDIN-2-OL(381233-75-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 381233-75-6(Hazardous Substances Data)

Usage

General Description

5-Bromo-3-iodo-pyridin-2-ol is a chemical compound with the molecular formula C5H3BrINO. It is a heterocyclic compound with a pyridine ring substituted with bromine and iodine atoms, as well as a hydroxyl group at the 2-position. 5-BROMO-3-IODO-PYRIDIN-2-OL is a versatile building block in organic synthesis and is commonly used in the pharmaceutical and agrochemical industries. Its unique structure and reactivity make it a valuable intermediate in the synthesis of various biologically active compounds. Additionally, 5-Bromo-3-iodo-pyridin-2-ol has potential applications in the development of new drugs and agrochemicals due to its pharmacological and pesticidal properties.

InChI:InChI=1/C5H3BrINO/c6-3-1-4(7)5(9)8-2-3/h1-2H,(H,8,9)

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 13466-38-1 5-bromopyridin-2(1H)-one 
• 381233-96-1 2-amino-3-iodo-5-bromopyridine 
• 13466-38-1 5-bromopyridin-2-ol 

Downstream Products

• 942589-70-0 5-bromo-3-((trimethylsilyl)ethynyl)pyridin-2-ol 
• 1361342-93-9 2-benzyloxy-5-bromo-3-iodo-pyridine 
• 1369499-48-8 4-(2-benzyloxy-5-bromo-pyridin-3-yl)phenol 
• 1369499-47-7 2-benzyloxy-5-bromo-3-(3-iodo-4-methoxyphenyl)pyridine 
• 1369499-46-6 5-allyl-3-(3-allyl-4-methoxyphenyl)pyridin-2-ol 
• 1369499-52-4 C₁₉H₁₄BrI₂NO₂ 
• 1369499-51-3 5-allyl-3-(3-allyl-4-methoxyphenyl)-2-benzyloxypyridine 
• 1369499-50-2 3-(3-allyl-4-methoxyphenyl)-2-benzyloxy-5-bromopyridine 
• 1369499-49-9 2-benzyloxy-5-bromo-3-(4-methoxyphenyl)pyridine 
• 1215107-69-9 methyl 2-(4-fluorophenyl)-5-(2-methyl-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)furo[2,3-b]pyridine-3-carboxylate 
• 1215107-67-7 5-(2-chloro-5-(1-(pyridin-2-yl)cyclopropylcarbamoyl)phenyl)-2-(4-fluorophenyl)furo[2,3-b]pyridine-3-carboxylic acid 
• 1215107-09-7 tert-butyl 3-(2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-b]pyridin-5-yl)-4-methylbenzoate 
• 1215107-08-6 5-(5-(tert-butoxycarbonyl)-2-methylphenyl)-2-(4-fluorophenyl)furo[2,3-b]pyridine-3-carboxylic acid 
• 1215107-06-4 methyl 5-(5-(tert-butoxycarbonyl)-2-methylphenyl)-2-(4-fluorophenyl)furo[2,3-b]pyridine-3-carboxylate 

Relevant articles and documents

PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS

The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

Br vs. TsO Chemoselective Suzuki–Miyaura Cross-Coupling Reaction on Nicotinaldehyde Moiety for the Preparation of 2,3,5-Trisubstituted Pyridines

Br vs. TsO chemoselective pallado-catalyzed Suzuki–Miyaura reaction has been developed from the 5-bromo-2-tosyloxynicotinaldehyde for the preparation of polysubstituted pyridines. This methodology has been applied for the preparation of a terpyridine alde

BTK INHIBITOR

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