94271-52-0

Usage

Uses

Used in Organic Chemistry:
BENZYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE is used as a building block for synthesizing various organic compounds due to its unique structure and reactivity.
Used in Medicinal Chemistry:
It serves as an intermediate in the production of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications.
Used in Material Science:
BENZYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE is used in the development of new materials with unique properties, leveraging its chemical structure to create innovative substances with specific characteristics.
Used in Agrochemical Production:
BENZYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE is also utilized as an intermediate in the synthesis of agrochemicals, playing a role in the creation of products designed to enhance agricultural productivity and crop protection.

Upstream product

• 634153-63-2 N-benzyl-3,4,5-trimethoxybenzaldimine 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 100-46-9 benzylamine 
• 18638-99-8 3,4,5-trimethoxybenzylamine 
• 100-52-7 benzaldehyde 
• 189245-78-1 N-((3,4,5-trimethoxyphenyl)methylene)benzenemethanamine 

Downstream Products

• 94271-55-3 diethyl N-benzyl-N-(3,4,5-trimethoxybenzyl)aminomalonate 
• 189245-78-1 N-((3,4,5-trimethoxyphenyl)methylene)benzenemethanamine 
• 101491-35-4 C₂₀H₂₅NO₆ 
• 780-25-6 N-benzylidene benzylamine 
• 94271-51-9 2-[(2-Chloro-acetyl)-(3,4,5-trimethoxy-benzyl)-amino]-malonic acid diethyl ester 
• 94271-47-3 4-Oxo-1-(3,4,5-trimethoxy-benzyl)-azetidine-2,2-dicarboxylic acid diethyl ester 
• 94271-56-4 diethyl (3,4,5-trimethoxybenzylamino)malonate 

Relevant academic research and scientific papers

A facile synthesis of stable β-amino-N-/O-hemiacetals through a catalyst-free three-component Mannich-type reaction

A practical, straightforward and one-step procedure for the synthesis of novel and stable β-amino-N-/O-hemiacetals (i.e. γ-aminoalcohols) is provided. The title compounds were obtained in good to excellent yields through an uncatalyzed three-component reaction by treatment of secondary amines with polyformaldehyde and electron-rich alkenes in acetonitrile as solvent at ambient temperature. The reactions proceeded with the formation of iminium ions, through a Mannich-type reaction, as the key intermediates for the generation of the target products. Single crystal X-ray analysis of derivative 4l confirmed unequivocally the structure and stability of the obtained compounds.

Graphene-supported NiPd alloy nanoparticles: A novel and highly efficient heterogeneous catalyst system for the reductive amination of aldehydes

A novel and highly efficient heterogeneous catalytic reductive amination of aldehydes is described. The recently developed graphene supported NiPd alloy nanoparticle (G-NiPd) catalyst using ammonia borane (AB) as a green, stable and safe hydrogen donor was used in a water/methanol mixture (v/v = 2/3) under ambient conditions. The catalytic system was successfully applied in the reductive amination of various substituted aldehydes with amines and the corresponding products were obtained in (up to) 99% yield in 6 h. The G-NiPd catalyst could be recycled up to five times without any significant loss in the product yield.

Secondary amines: Synthesis and effect of length of spacer linking two phenyl rings on biological activity

N-Benzyl benzylamines (1a-11a) and N-benzyl anilines (1b-11b) were synthesized by sodium borohydride reduction of aldimines of benzylamine and aniline respectively. The products were characterized on the basis of elemental analysis and spectral studies and screened for antifungal potential against four fungi and evaluated for nematicidal activity against two nematodes. The former compounds were found to be more effective as compared to the latter thus indicating an enhancement of biological activity due to introduction of an extra methylene group between two phenyl rings of aromatic secondary amines.

Use of polymer supported reagents for clean multi-step organic synthesis: Preparation of amines and amine derivatives from alcohols for use in compound library generation

The automated sequential application of polymer supported perruthenate (PSP) and polymer supported cyanoborohydride (PSCBH) in an oxidation-reductive amination procedure allowed the efficient transformation of simple alcohols into more complex amines which can be further derivatised by the use of polymer bound amino sulfonylpyridinium chlorides.