94278-74-7

Upstream product

• 132409-37-1 C₃₀H₃₆O₃ 
• 132488-16-5 C₃₀H₃₆O₃ 
• 132488-22-3 C₃₀H₃₆O₃ 
• 74183-62-3 (1RS,4'R)-1-<2',2'-Dimethyl-1',3'-dioxolan-4'-yl>aethanol 
• 132409-34-8 (E)-(2S,5S)-1-Benzyloxy-3,5-dimethyl-hept-3-ene-2,6-diol 
• 132409-34-8 (E)-(S)-1-Benzyloxy-3,5-dimethyl-hept-3-ene-2,6-diol 
• 100-39-0 benzyl bromide 

Downstream Products

• 1229648-63-8 (S)-N-[3,4-bis(benzyloxy)butan-2-ylidene]-1-phenylmethanamine 
• 1229648-62-7 (2S,3S)-N-benzyl-3,4-bis(benzyloxy)butan-2-amine 
• 175730-15-1 (2R,3S)-N-benzyl-3,4-bis(benzyloxy)butan-2-amine 

Relevant academic research and scientific papers

Diastereoselective reduction of ketimines derived from (R)-3,4-dihydroxybutan-2-one: an alternative route to key intermediates for the synthesis of anticancer agent ES-285

A simple and convenient procedure for the diastereoselective reduction of imines derived from (R)-3,4-dihydroxybutan-2-one is described. The use of sodium borohydride as a reducing agent in the reactions with pre-synthesised imines gave aminodiol derivatives with the appropriate stereochemistry for use as intermediates in the synthesis of anticancer agent ES-285. The aminodiols were isolated in ca. 62% yield.

Diastereodifferentiation in SN2' Additions of Methylcuprates to Nonracemic Acyclic Vinyloxiranes

SN2' additions of Me2CuLi, MeCu(CN)Li, and Me2Cu(CN)Li2 to the 2S and 2R alkoxy cis-(Z)- and -(E)-vinyloxiranes 8, 9, 13, and 14 were examined as possible routes to acyclic subunits of polypropionate natural products.Highest anti:syn ratios wer