942895-18-3Relevant academic research and scientific papers
The Mannich reaction in the synthesis of N,S-containing heterocycles : 55*5. Synthesis and structures of new pyrimido[2,1-b][1,3,5] thiadiazine derivatives
Dotsenko,Krivokolysko,Rusanov,Litvinov
, p. 1437 - 1440 (2008/09/17)
Reactions of 6-aryl-5-cyano-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidines with formaldehyde and primary amines gave earlier unknown 3,4-dihydro-2H,6H- pyrimido[2,1-b]-[1,3,5]thiadiazine derivatives in 58-94% yields. In boiling AcOH, these pyrimidothiadiazines underwent the retro-Mannich reaction leading to the starting pyrimidine-2-thiones. The structure of 3-(4-ethoxyphenyl)-6-oxo-8- phenyl-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3,5]thiadiazine-7-carbonitrile was studied by X-ray diffraction analysis.
