942922-07-8

Basic information

• Product Name: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER
• Synonyms: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER;2-(4-Methylpiperazino)pyrimidine-5-boronic acid pinacol ester;2-(4-Methylpiperazin-1-yl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidine;2-(4-methyl-1-piperazinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
• CAS NO: 942922-07-8
• Molecular Formula: C₁₅H₂₅BN₄O₂
• Molecular Weight: 304.2
• Product Categories: Organoborons;Pyrimidine
• Mol File: 942922-07-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 445.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.44±0.42(Predicted)
• CAS DataBase Reference: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(942922-07-8)
• EPA Substance Registry System: 2-(4-METHYLPIPERAZIN-1-YL)PYRIMIDINE-5-BORONIC ACID PINACOL ESTER(942922-07-8)

Safety Data

• Hazardous Substances Data: 942922-07-8(Hazardous Substances Data)

Usage

General Description

2-(4-Methylpiperazin-1-yl)pyrimidine-5-boronic acid pinacol ester is a chemical compound with potential applications in medicinal and pharmaceutical research. It is a boronic acid ester derivative, which is a widely used class of compounds in the field of drug discovery and development. This particular compound contains a pyrimidine ring with a boronic acid functional group and a pinacol ester moiety, making it suitable for use in Suzuki-Miyaura cross-coupling reactions and other synthetic methodologies. The presence of the 4-methylpiperazine group also suggests potential interactions with biological targets such as receptors and enzymes, making it a valuable tool for the design and synthesis of biologically active molecules. Overall, 2-(4-Methylpiperazin-1-yl)pyrimidine-5-boronic acid pinacol ester is a versatile and valuable chemical building block for medicinal chemistry and drug discovery research.

Upstream product

• 141302-36-5 5-bromo-2-(4-methylpiperazin-1-yl)pyrimidine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1092367-94-6 N-(2-chloro-6-methylphenyl)-2-(2-methyl-2'-(4-methylpiperazin-1-yl)-4,5'-bipyrimidin-6-ylamino)thiazole-5-carboxamide 

Relevant articles and documents

1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.

AZAINDOLE INHIBITORS OF AURORA KINASES

The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including s