942941-99-3Relevant academic research and scientific papers
PTP1B inhibitors
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Page/Page column 22, (2010/11/29)
This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1b (PTP1b).
Probing acid replacements of thiophene PTP1B inhibitors
Wan, Zhao-Kui,Follows, Bruce,Kirincich, Steve,Wilson, Douglas,Binnun, Eva,Xu, Weixin,Joseph-McCarthy, Diane,Wu, Junjun,Smith, Michael,Zhang, Yan-Ling,Tam, May,Erbe, David,Tam, Steve,Saiah, Eddine,Lee, Jinbo
, p. 2913 - 2920 (2008/02/02)
The following account describes our systematic effort to replace one of the carboxylate groups of our diacid thiophene PTP1B inhibitors. Active hits were validated using enzymatic assays before pursuing efforts to improve the potency. Only when the C2 car
