942996-03-4

Usage

Physical State

White crystalline solid

Molecular Weight

221.2 g/mol

Common Uses

Intermediate in pharmaceutical and agrochemical synthesis

Functional Groups

Amino group ( -\textNH2 )
Phenyl group ( -\textC6\textH5 )
Trifluoromethoxy group ( -\textCF3\textO )

Chemical Reactions

Participates in various chemical reactions due to its functional groups

Potential Applications

Building block for the development of new drugs and bioactive molecules

Health Hazards

Caution required due to potential skin and eye irritation

Upstream product

• 261952-24-3 2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid 

Downstream Products

• 1227147-84-3 2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-1,3-oxazole 
• 1227148-15-3 2-[1-Methyl-5-(4-methylbenzyl)-1H-pyrazol-3-yl]-4-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1,3-oxazole 
• 1227148-14-2 N-{2-Hydroxy-1-[4-(trifluoromethoxy)phenyl]ethyl}-1-methyl-5-(4-methylbenzyl)-1H-pyrazole-3-carboxamide 
• 1571034-03-1 N-(2-hydroxy-1-(4-(trifluoromethoxy)phenyl)ethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide 
• 1571034-10-0 5-(4-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one 
• 1571034-06-4 5-(4-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazol-2-yl)pyridin-2(1H)-one 

Relevant academic research and scientific papers

Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions

The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C?N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive molecules. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and density functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N?H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer.

HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS

The present application relates to novel substituted aryl compounds, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.