942996-06-7

Upstream product

• 1073477-18-5 4,4,4-trifluoro-2-phenylbutanoic acid 
• 1602484-95-6 (1-azido-3,3,3-trifluoropropyl)benzene 
• 100-42-5 styrene 

Downstream Products

• 1602485-80-2 C₁₇H₁₆F₃NO₂ 

Relevant academic research and scientific papers

BENZIMIDAZOLE DERIVATIVES AND USE THEREOF AS IDH1 INHIBITORS

The present invention relates to benzimidazole compounds and an application thereof as IDH1 mutant inhibitors, in particular, to a compound as represented by formula (I), tautomers thereof, or pharmaceutically acceptable salts thereof.

Copper-Catalyzed Three-Component Azidotrifluoromethylation/Difunctionalization of Alkenes

A novel three-component strategy for the azidotrifluoromethylation of alkenes has been presented here. The reaction proceeded smoothly under gentle temperature and gave the bifunctional olefins in high yields. Furthermore, 1,3-dipolar reactions between az

Copper-catalyzed intermolecular trifluoromethylazidation of alkenes: Convenient access to CF3-containing alkyl azides

A novel copper-catalyzed intermolecular trifluoromethylazidation of alkenes has been developed under mild reaction conditions. A variety of CF 3-containing organoazides were directly synthesized from a wide range of olefins, including activated and unactivated alkenes, and the resulting products can be easily transformed into the corresponding CF3- containing amine derivatives. The title reaction proceeds with a CF 3+ reagent under mild reaction conditions. This transformation presents a broad substrate scope and good functional-group tolerance. A variety of CF3-containing organoazides are directly synthesized from a wide range of olefins, including activated and unactivated alkenes. The resulting products are easily transformed into the corresponding amine derivatives. Copyright

PhI(OAc)2-mediated radical trifluoromethylation of vinyl azides with Me3SiCF3

The fluorine-containing organic motif is becoming privileged in pharmaceuticals, agrochemicals, and functional materials, owing to its unique properties such as electron-withdrawing character, metabolic stability, and lipophilicity. Described herein is the PhI(OAc)2-mediated radical trifluoromethylation of vinyl azides with Me3SiCF3 to efficiently generate α-trifluoromethyl azines. The resulting α-trifluoromethyl azines were successfully transformed to valuable fluorine-containing molecules such as α-trifluoromethyl ketones, β-trifluoromethyl amines, 5-fluoropyrazoles, and trifluoroethyl isoquinolines. Trifluoromethylated diversity: The title reaction (see scheme) efficiently leads to α-trifluoromethyl azines, which were successfully transformed into valuable fluorine-containing molecules such as α-trifluoromethyl ketones, β-trifluoromethyl amines, 5-fluoropyrazoles, and trifluoroethyl isoquinolines. Copyright

PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 ("GPR119") in a patient.