943025-77-2Relevant academic research and scientific papers
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases
Miles, Timothy J.,Hennessy, Alan J.,Bax, Ben,Brooks, Gerald,Brown, Barry S.,Brown, Pamela,Cailleau, Nathalie,Chen, Dongzhao,Dabbs, Steven,Davies, David T.,Esken, Joel M.,Giordano, Ilaria,Hoover, Jennifer L.,Huang, Jianzhong,Jones, Graham E.,Kusalakumari Sukmar, Senthill K.,Spitzfaden, Claus,Markwell, Roger E.,Minthorn, Elisabeth A.,Rittenhouse, Steve,Gwynn, Michael N.,Pearson, Neil D.
, p. 5437 - 5441 (2013)
During the course of our research to find novel mode of action antibacterials, we discovered a series of hydroxyl tricyclic compounds that showed good potency against Gram-positive and Gram-negative pathogens. These compounds inhibit bacterial type IIA to
HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIALS
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Page/Page column 26; 31, (2008/06/13)
Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials .
