94309-18-9Relevant academic research and scientific papers
I2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines
Li, Yazhou,Liang, Xuewu,Liu, Hong,Liu, Qi,Liu, Xuyi,Wei, Xiaohui,Zhou, Yu
supporting information, p. 9165 - 9171 (2021/11/23)
The spiroindolenine framework is a privileged heterocyclic motif and is widely present in numerous indole alkaloids. Herein, we develop a metal-free and environmentally friendly approach for the intramolecular cascade cyclization and dearomatization of indole derivatives to selectively afford iodinated and vinylic spiroindolenines by a substrate-controlled strategy. Simple operation, mild conditions, and high yield make this strategy a green and attractive pathway to construct functionalizable spiroindolenine scaffolds, which could be converted into diverse useful spiroindolenine derivatives.
