943138-88-3

Basic information

• Product Name: C₂₁H₂₄FNO₇S
• Synonyms: C₂₁H₂₄FNO₇S
• CAS NO: 943138-88-3
• Molecular Weight: 453.488
• Mol File: 943138-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₄FNO₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₄FNO₇S(943138-88-3)
• EPA Substance Registry System: C₂₁H₂₄FNO₇S(943138-88-3)

Safety Data

• Hazardous Substances Data: 943138-88-3(Hazardous Substances Data)

Upstream product

• 67765-42-8 5-methoxy-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione 
• 53600-33-2 6-methoxyanthranilic acid 
• 955937-58-3 C₂₂H₂₄FNO₇S 
• 943138-83-8 C₂₀H₂₁BrFNO₇S 
• 943138-78-1 C₁₄H₁₈BrNO₅ 
• 681247-11-0 methyl 6-amino-3-bromo-2-hydroxybenzoate 
• 681247-10-9 6-bromo-5-hydroxy-2H-3,1-benzoxazine-2,4(1H)-dione 
• 681247-09-6 6-bromo-5-methoxy-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione 
• 955937-60-7 C₂₂H₂₆FNO₇S 

Relevant articles and documents

Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids

A series of aryl sulfonamides of 5,6-disubstituted anthranilic acids were identified as potent inhibitors of methionine aminopeptidase-2 (MetAP2). Small alkyl groups and 3-furyl were tolerated at the 5-position of anthranilic acid, while -OCH3, CH3, and Cl were found optimal for the 6-position. Placement of 2-aminoethoxy group at the 6-position enabled interaction with the second Mn2+ but did not result in enhancement in potency. Introduction of a tertiary amino moiety at the ortho-position of the sulfonyl phenyl ring gave reduced protein binding and improved cellular activity, but led to lower oral bioavailability.