943151-62-0Relevant academic research and scientific papers
Isoxazole-assisted direct substitution of the hydroxy group in α-ketols: Introduction of angular substituents in a polycyclic system
Takikawa, Hiroshi,Hikita, Katsuyoshi,Suzuki, Keisuke
supporting information; experimental part, p. 9887 - 9890 (2009/05/07)
(Chemical Equation Presented) The facile introduction of an angular substituent has become viable for the synthesis of natural products such as 2. Ketol 1 serves to achieve this through the direct substitution of its hydroxy group by a Lewis acid (see sch
Isoxazole-directed pinacol rearrangement: Stereocontrolled approach to angular stereogenic centers
Suzuki, Keisuke,Takikawa, Hiroshi,Hachisu, Yoshifumi,Bode, Jeffrey W.
, p. 3252 - 3254 (2008/02/14)
(Chemical Equation Presented) Underappreciated and neglected, isoxazoles are extremely good at stabilizing α cations. This ability is exploited in a method for the stereocontrolled introduction of angular substituents as found in polyketide-derived polycy
