943310-56-3

Usage

Structure

A boronic acid derivative containing a boron atom bonded to a phenyl ring with a fluorine substituent and a methoxymethoxymethyl group.

Usage

Commonly used as a reagent in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds.

Reactivity

The boronic acid functionality allows it to participate in Suzuki-Miyaura cross-coupling reactions.

Applications

Versatile building block for the synthesis of pharmaceuticals, agrochemicals, and materials.

Upstream product

• 845301-93-1 2-bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzene 
• 5419-55-6 Triisopropyl borate 
• 202865-66-5 2-bromo-5-fluorobenzyl alcohol 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 

Downstream Products

• 174671-46-6 tavaborole 

Relevant academic research and scientific papers

Benzoxaborole-1-alcohol compound and preparation method and application thereof

The invention belongs to the field of bactericides, and particularly relates to a benzoxaborole-1-alcohol compound and a preparation method and application thereof. The benzoxaborole-1-alcohol compound has good bactericidal activity, can effectively control tomato early blight, wheat scab, rice sheath blight disease, strawberry gray mold, apple blotch, cucumber anthracnose and other crop diseases,can produce excellent antibacterial effects at low concentration, and shows good selectivity. The compound is used as a leucyl-tRNA synthetase inhibitor, the evolution difference of aminoacyl-tRNA synthetase of germs and eukaryotes is utilized, and the compound has very high safety to non-target organisms while killing the germs and can be used as a bactericide in agriculture.

Compounds for the Treatment of Periodontal Disease

Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.

Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use

Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.