943323-02-2

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 174885-99-5 (±)-tert-butyl N-(2-amino-2-phenylethyl)carbamate 

Downstream Products

• 943323-03-3 1,1-dimethylethyl {2-phenyl-2-[({5-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thienyl}methyl)amino]ethyl}carbamate 

Relevant academic research and scientific papers

Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors

A pyrrolopyridinyl thiophene carboxamide 7 was discovered as a tractable starting point for a lead optimization effort in an AKT kinase inhibition program. SAR studies aided by a co-crystal structure of 7 in AKT2 led to the identification of AKT inhibitor

INHIBITORS OF Akt ACTIVITY

Invented are novel thiophene compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.