943324-07-0

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-2-Methyl-1-(phenylsulfonyl)-
• Synonyms: 3-iodo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;3-Iodo-2-methyl-1-(phenylsulfonyl)-7-azaindole;1H-Pyrrolo[2,3-b]pyridine, 3-iodo-2-Methyl-1-(phenylsulfonyl)-
• CAS NO: 943324-07-0
• Molecular Formula: C₁₄H₁₁IN₂O₂S
• Molecular Weight: 398.21881
• Mol File: 943324-07-0.mol

Chemical Properties

• Boiling Point: 538.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.76±0.1 g/cm3(Predicted)
• PKA: 0.54±0.30(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-2-Methyl-1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-2-Methyl-1-(phenylsulfonyl)-(943324-07-0)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-2-Methyl-1-(phenylsulfonyl)-(943324-07-0)

Safety Data

• Hazardous Substances Data: 943324-07-0(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
1H-Pyrrolo[2,3-b]pyridine, 3-iodo-2-methyl-1-(phenylsulfonyl)is used as a chemical intermediate for the development of new pharmaceuticals. Its unique structure allows for potential interactions with biological targets, making it a promising candidate for the creation of novel therapeutic agents.
Used in Drug Development:
In the pharmaceutical industry, 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-2-methyl-1-(phenylsulfonyl)is utilized as a key component in the synthesis of various drug molecules. Its presence in these compounds may contribute to their pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Organic Chemistry Research:
1H-Pyrrolo[2,3-b]pyridine, 3-iodo-2-methyl-1-(phenylsulfonyl)serves as a subject of study for researchers in organic chemistry. Its synthesis and properties are investigated to understand the reactivity and behavior of similar compounds, which can lead to the discovery of new reactions and applications in the field.

Upstream product

• 887115-53-9 3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 74-88-4 methyl iodide 
• 80360-21-0 1-(benzenesulfonyl)-2-methyl-1H-indole 

Downstream Products

• 943324-08-1 1-benzenesulfonyl-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1256964-50-7 3-iodo-2-methylpyrrolo[2,3-b]pyridine 

Relevant articles and documents

Application of selective palladium-mediated functionalization of the pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine heterocyclic system for the total synthesis of variolin B and deoxyvariolin B

The reaction of protected 3-bromo-2-(bromomethyl)-4-methoxypyrrolo[2,3-b] pyridine and tosylmethyl isocyanide (TosMIC) afforded a pyrido[3′, 2′:4,5]pyrrolo[1,2-c]pyrimidine derivative in good yield. This compound was transformed through installation of the pyrimidine moiety in the C5 position, hydrolysis, and decarboxylation in an advanced intermediate for the total or formal synthesis of the naturalalkaloid variolin B. Reaction of 3-bromo-2-(bromomethyl)-4-chloropyrrolo[2,3-b]pyridine with N-tosylmethyl dichloroformimide as a synthetic TosMIC equivalent afforded trihalo-substituted pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine. This compound was used in a new total synthesis of the alkaloid variolin B by selective and sequential C-N, C-C, and C-O palladium-mediated functionalization at the C9, C5, and C4 positions of the pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine system. A formal synthesis of deoxyvariolin B is also described by using the same synthetic strategy. A new synthesis for deoxyvariolin B and the natural product variolin B was achieved by selective and sequential palladium-mediated functionalization of di- or trihalo-substituted pyrido[3′,2′:4,5] pyrrolo[1,2-c]pyrimidine.

INHIBITORS OF Akt ACTIVITY

Invented are novel thiophene compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.