1256964-50-7

Basic information

• Product Name: 3-iodo-2-Methyl-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 3-iodo-2-Methyl-1H-pyrrolo[2,3-b]pyridine;3-Iodo-2-Methyl-7-azaindole
• CAS NO: 1256964-50-7
• Molecular Formula: C₈H₇IN₂
• Molecular Weight: 258.05905
• EINECS: -0
• Mol File: 1256964-50-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-iodo-2-Methyl-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-iodo-2-Methyl-1H-pyrrolo[2,3-b]pyridine(1256964-50-7)
• EPA Substance Registry System: 3-iodo-2-Methyl-1H-pyrrolo[2,3-b]pyridine(1256964-50-7)

Safety Data

• Hazardous Substances Data: 1256964-50-7(Hazardous Substances Data)

Usage

General Description

3-Iodo-2-Methyl-1H-pyrrolo[2,3-b]pyridine is a specialized chemical compound falling under the category of heterocyclic compounds, more specifically it is a halogenated heterocyclic compound. Due to its pyrrolo[2,3-b]pyridine base, it displays properties characteristic of both pyridines and pyrroles. Its molecular formula is C8H6IN3, indicating that it is composed of carbon, hydrogen, nitrogen, and iodine. 3-iodo-2-Methyl-1H-pyrrolo[2,3-b]pyridine is predominantly used in research and development environments, particularly the fields of pharmaceuticals and drug design. Its unique structural characteristics make it useful in the synthesis of a range of pharmaceuticals and biologically active compounds.

Upstream product

• 23612-48-8 2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 943324-07-0 3-Iodo-2-methyl-1-(phenylsulfonyl)pyrrolo[2,3-b]pyridine 

Downstream Products

• 1254926-31-2 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1316228-33-7 C₂₂H₂₃N₅O₂ 
• 1375277-41-0 (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-(2-hydroxyethyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetamido)-N-methyl-3-phenylpropanamide 
• 1375277-40-9 (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(3-ethyl-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetamido)-N-methyl-3-phenylpropanamide 
• 1375278-66-2 (S)-N-(benzo[d][1,3]dioxol-5-yl)-N-methyl-2-(2-(2-methyl-3-vinyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetamido)-3-phenylpropanamide 

Relevant articles and documents

NOVEL ANTIVIRAL COMPOUNDS

The present invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing a viral infection such as HIV using the same.

Application of selective palladium-mediated functionalization of the pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine heterocyclic system for the total synthesis of variolin B and deoxyvariolin B

The reaction of protected 3-bromo-2-(bromomethyl)-4-methoxypyrrolo[2,3-b] pyridine and tosylmethyl isocyanide (TosMIC) afforded a pyrido[3′, 2′:4,5]pyrrolo[1,2-c]pyrimidine derivative in good yield. This compound was transformed through installation of the pyrimidine moiety in the C5 position, hydrolysis, and decarboxylation in an advanced intermediate for the total or formal synthesis of the naturalalkaloid variolin B. Reaction of 3-bromo-2-(bromomethyl)-4-chloropyrrolo[2,3-b]pyridine with N-tosylmethyl dichloroformimide as a synthetic TosMIC equivalent afforded trihalo-substituted pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine. This compound was used in a new total synthesis of the alkaloid variolin B by selective and sequential C-N, C-C, and C-O palladium-mediated functionalization at the C9, C5, and C4 positions of the pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine system. A formal synthesis of deoxyvariolin B is also described by using the same synthetic strategy. A new synthesis for deoxyvariolin B and the natural product variolin B was achieved by selective and sequential palladium-mediated functionalization of di- or trihalo-substituted pyrido[3′,2′:4,5] pyrrolo[1,2-c]pyrimidine.