943434-47-7

Upstream product

• 1014612-94-2 4-bromo-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide 
• 73183-34-3 bis(pinacol)diborane 
• 928656-94-4 pentafluorophenyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonate 
• 116529-31-8 1,1-dioxohexahydro-1λ6-thiopyran-4-ylamine hydrochloride 
• 210240-20-3 4-aminotetrahydro-2H-thiopyran-1,1-dioxide 
• 595597-01-6 1,1-dimethylethyl (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)carbamate 
• 6309-59-7 tetrahydro-4H-thiopyran-4-one oxime 
• 1072-72-6 Tetrahydrothiopyran-4-one 
• 21926-00-1 4-tetrahydrothiopyranylamine 

Downstream Products

• 1014612-95-3 4-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide 
• 1014613-02-5 N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(1-methylethenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide 
• 1187448-48-1 4-[2-(1,1-dimethylethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide 
• 1187448-54-9 4-(5-chloro-2-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide 
• 1187448-58-3 4-(2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide 
• 1187448-70-9 4-(5-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1,1-dioxotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide 

Relevant academic research and scientific papers

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.

NOVEL COMPOUNDS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.