943595-13-9

Usage

Uses

Used in Food and Beverage Industry:
Benzoic acid, 2-(bromoMethyl)-6-Methoxy-, Methyl ester is used as a flavoring agent to enhance the taste and aroma of various food and beverage products.
Used in Fragrance Industry:
Benzoic acid, 2-(broMoMethyl)-6-Methoxy-, Methyl ester is utilized in the production of fragrances, contributing to the creation of unique and appealing scents for a wide range of products.
Used in Pharmaceutical Industry:
Benzoic acid, 2-(bromoMethyl)-6-Methoxy-, Methyl ester serves as a chemical intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new medications.
Used in Organic Synthesis:
As a chemical intermediate, Benzoic acid, 2-(bromoMethyl)-6-Methoxy-, Methyl ester is employed in organic synthesis to produce a variety of chemical compounds for different applications.
It is important to handle this chemical with care, as it can be harmful if ingested or inhaled, and can cause irritation to the skin and eyes. Proper safety procedures should be followed when working with Benzoic acid, 2-(broMoMethyl)-6-Methoxy-, Methyl ester to avoid any potential hazards.

Upstream product

• 567-61-3 2-hydroxy-6-methylbenzoic acid 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 6161-65-5 2-methoxy-6-methyl-benzoic acid 
• 79383-44-1 methyl 2-methyl-6-methoxybenzoate 

Downstream Products

• 82780-51-6 (+/-)-3-(4-methoxyphenyl)-8-methoxy-3,4-dihydroisocoumarin 
• 480-47-7 hydrangenol 
• 1213268-09-7 methyl 2-{(benzo[d]thiazol-2-ylthio)methyl}-6-methoxybenzoate 
• 960506-47-2 diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate 
• 960506-46-1 diethyl [(2-hydroxymethyl)-3-methoxybenzylsulfonyl]methylphosphonate 
• 960506-52-9 C₁₄H₂₃SPO₅ 
• 857652-04-1 2-(bromomethyl)-6-methoxybenzyl alcohol 
• 104172-27-2 (2-carbomethoxy-3-methoxybenzyl)triphenylphosphonium bromide 
• 104156-21-0 2-[2-(3-Carboxymethyl-phenyl)-ethyl]-6-methoxy-benzoic acid methyl ester 
• 104156-22-1 3-<2-(2-carboxy-3-methoxyphenyl)ethyl>phenylacetic acid 
• 104156-23-2 2-[2-(3-Chlorocarbonylmethyl-phenyl)-ethyl]-6-methoxy-benzoyl chloride 
• 104156-20-9 2-[(Z)-2-(3-Carboxymethyl-phenyl)-vinyl]-6-methoxy-benzoic acid methyl ester 

Relevant academic research and scientific papers

TREATING LONG QT SYNDROME

This document relates to compounds useful for treating and preventing disorders associated with long QT syndrome such as cardiac arrhythmia, ventricular arrhythmia, hypertrophic cardiomyopathy, and congestive heart failure. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient.

Copper-Catalyzed One-Pot Synthesis of Dibenzofurans, Xanthenes, and Xanthones from Cyclic Diphenyl Iodoniums

Oxygenation of cyclic diphenyl iodoniums (CDPIs) with varied medium-ring sizes has been fully investigated. This practical copper-catalyzed tandem reaction of CDPIs with water as the oxygen source enables the construction of derivatised dibenzofurans and xanthenes at moderate to good yields. Moreover, structurally important xanthones are also successfully accessed under the oxygenation conditions with additional TEMPO.

HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF

The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein by administering a HAT modulator and a HDAC modulator to a subject.

Assessment of the regioselectivity in the condensation reaction of unsymmetrical o-phthaldialdehydes with alanine

One approach for the synthesis of isoindolinones, a privileged bioactive heterocyclic core structure, involves a condensation reaction of o-phthaldialdehydes with a suitable nitrogen-containing nucleophile. This fascinating reaction is revisited here in the context of the use of o-phthaldialdehydes that contain additional substituents in the aromatic ring leading to a detailed analysis of the regioselectivity of the reaction. Eleven monosubstituted o-phthaldialdehydes were synthesised and reacted with alanine. The regioselectivity observed across the eleven substrates led to the design of a disubstituted substrate that reacted with very high control. A gram-scale reaction followed by esterification gave one major regioisomer in high yield. In addition, the regioselectivity observed on reaction of two novel monodeuterated substrates led to an increased mechanistic understanding.

HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF

The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

A series of analogs of the immunomodulary drugs lenalidomide (1) and pomalidomide (2), in which the amino group is replaced with various isosteres, was prepared and assayed for immunomodulatory activity and activity against cancer cell lines. The 4-methyl and 4-chloro analogs 4 and 15, respectively, displayed potent inhibition of tumor necrosis factor-α (TNF-α) in LPS-stimulated hPBMC, potent stimulation of IL-2 in a human T cell co-stimulation assay, and anti-proliferative activity against the Namalwa lymphoma cell line. Both of these analogs displayed oral bioavailability in rat.

Metabolically stable dibenzo[ b, e ]oxepin-11(6 H)-ones as highly selective p38 MAP kinase inhibitors: Optimizing anti-cytokine activity in human whole blood

Five series of metabolically stable disubstituted dibenzo[b,e]oxepin-11(6H) -ones were synthesized and tested in a p38α enzyme assay for their inhibition of tumor necrosis factor-α (TNF-α) release in human whole blood. Compared to the monosubstituted dibenzo[b,e]oxepin-11(6H)-one derivatives, it has been shown that the additional introduction of hydrophilic residues at position 9 leads to a substantial improvement of the inhibitory potency and metabolic stability. Using protein X-ray crystallography, the binding mode of the disubstituted dibenzoxepinones and the induction of a glyince flip in the hinge region were confirmed. The most potent compound of this series, 32e, shows an outstanding biological activity on isolated p38α, with an IC50 value of 1.6 nM, extraordinary selectivity (by a factor >1000, Kinase WholePanelProfiler), and low ATP competitiveness. The ability to inhibit the release of TNF-α from human whole blood was optimized down to an IC50 value of 125 nM. With the promising dibenzoxepinone inhibitor 3i, a pharmacokinetic study in mice was conducted.

Synthesis of (+)-varitriol analogues via novel and versatile building blocks based on julia olefination

The synthesis of (+)-varitriol (1) analogues was achieved through, the use of Julia olefination. The potential anticancer properties of 1 coupled with, our interest in developing building blocks that enable olefin formation under the Julia protocol constitute the basis of our research project. Efforts are aimed at the synthesis of building blocks 2 and 3 and to explore their use towards the synthesis of (+)-varit:riol analogues. Herein, we would, like to present the synthesis of building block 3 and its ability to react with variety of substituted aromatic-, heterocyclic- and carbohydrate-derived aldehydes to yield alkene 6 in moderate to good yields with E as the major isomer. The successful, coupling of 2 with (furanoside moieties) aldehydes 5k, 5m and 5n in particular and the obtainment of compound 23 reflect the promise associated with the new strategy.

Titanocene(III) chloride mediated radical-induced synthesis of 3,4-dihydroisocoumarins: synthesis of (±)-hydrangenol, (±)-phyllodulcin, (±)-macrophyllol and (±)-thunberginol G

A radical-promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of four naturally occurring dihydrocoumarins hydrangenol, phyllodulcin, macrophyllol and thunberginol G has been accomplished using the radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon.

Radical-mediated synthesis of 3,4-dihydroisocoumarins: total synthesis of hydrangenol

A radically promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of (±)-hydrangenol has been completed using this radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon.