943598-89-8Relevant academic research and scientific papers
Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents
Tatsuzaki, Jin,Bastow, Kenneth F.,Nakagawa-Goto, Kyoko,Nakamura, Seiko,Itokawa, Hideji,Lee, Kuo-Hsiung
, p. 1445 - 1449 (2008/12/21)
Twenty-eight compounds related to dehydrozingerone (1), isoeugenol (3), and 2-hydroxychalcone (4) were synthesized and evaluated in vitro against human tumor cell replication. Except for isoeugenol analogues 27-35, most compounds exhibited moderate or strong cytotoxic activity against KB, KB-VCR (a multidrug-resistant derivative), and A549 cell lines. In particular, chalcone 15 showed significant cytotoxic activity against the A549 cell line with an IC50 value of 0.6 μg/mL. Furthermore, dehydrozingerone analogue 11 and chalcones 16 and 17 showed significant and similar cytotoxic activity against both KB (IC50 values of 2.0, 1.0, and 2.0 μg/mL, respectively) and KB-VCR (IC50 values of 1.9, 1.0, and 2.0 μ/mL, respectively) cells, suggesting that they are not substrates for the P-glycoprotein drug efflux pump.
