599-91-7Relevant articles and documents
Copper-Catalyzed Multicomponent Reaction of DABCO·(SO2)2, Alcohols, and Aryl Diazoniums for the Synthesis of Sulfonic Esters
Wang, Yang,Deng, Lingling,Deng, Yu,Han, Jianlin
, p. 4674 - 4680 (2018/04/26)
A Cu-catalyzed multicomponent cascade reaction of DABCO·(SO2)2 (DABSO), alcohol, and aryl diazonium tetrafluoroborate was developed which afforded sulfonic esters in moderate to good chemical yields. In this reaction, the SO2 surrogate DABSO was used for the first time in the synthesis of sulfonic aliphatic esters. This multicomponent reaction was carried out under mild conditions and tolerated a wide range of substrates, which provides a new and efficient strategy for the synthesis of sulfonic esters.
New process for the production of alkyltosylate from alcohol and para-toluene sulfonic acid
-
Paragraph 0026; 0027, (2016/12/16)
The present invention relates to a new method for producing an alkyltosylate derivative which plays an important role in transforming a hydroxy group of alcohol into other usage intermediate in a process of synthesizing core intermediates in a fine chemical field such as medicines, agricultural chemicals, dyes, electronic materials, etc. The present invention, as compared with previous technologies which has a long preprocess time for acquiring a catalyst to activate para-toluene sulfonic acid and needs an intense reaction condition in spite of using the catalyst, provides the new method for producing the alkyltosylate derivative having a characteristic of activating the para-toluene sulfonic acid under a warm condition equal to or lower than 25anddeg;C by making the para-toluene sulfonic acid react with the bis(trichloromethyl)carbonate, tribasic potassium phosphate and triethylamine with an amount of catalyst, and then making the para-toluene sulfonic acid react with alcohol, thereby contributing greatly to related industries such as dyes, agricultural chemicals, medicines, electronic materials, etc.COPYRIGHT KIPO 2015
Synthesis of structural analogues of hexadecylphosphocholine and their antineoplastic, antimicrobial and amoebicidal activity
Timko, Luká?,Fischer-Fodor, Eva,Garajová, Mária,Mrva, Martin,Chereches, Gabriela,Ondriska, Franti?ek,Bukovsky, Marián,Luká?, Milo?,Karlovská, Janka,Kubincová, Janka,Devínsky, Ferdinand
, p. 263 - 273 (2015/05/26)
Twelve derivatives of hexadecylphosphocholine (miltefosine) were synthesized to determine how the position and length of the alkyl chain within the molecule influence their biological activities. The prepared alkylphosphocholines have the same molecular formula as miltefosine. Activity of the compounds was studied against a spectrum of tumour cells, two species of protozoans, bacteria and yeast. Antitumour efficacy of some alkylphosphocholines measured up on MCF-7, A2780, HUT-78 and THP-1 cell lines was higher than that of miltefosine. The compounds showed antiprotozoal activity against Acanthamoeba lugdunensis and Acanthamoeba quina. Some of them also possess fungicidal activity against Candida albicans equal to miltefosine. No antibacterial activity was observed against Staphylococcus aureus and Escherichia coli. A difference in position of a long hydrocarbon chain within the structure with maximum efficacy was observed for antitumour, antiprotozoal and antifungal activity.