943602-77-5

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Amino-6-methylisoquinolin-1(2H)-one is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of complex molecular structures that can be tailored for specific therapeutic effects.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-Amino-6-methylisoquinolin-1(2H)-one is utilized as a building block for the creation of novel drug candidates, leveraging its structural features to enhance the potency, selectivity, and pharmacokinetic properties of new compounds.
Used in Organic Compound Synthesis:
5-Amino-6-methylisoquinolin-1(2H)-one is also used as a versatile intermediate in the synthesis of various organic compounds, where its amino and methyl groups can be further modified to achieve desired chemical properties and reactivity.
Used in Drug Development:
5-Amino-6-methylisoquinolin-1(2H)-one is employed in drug development as a structural scaffold to facilitate the design of new biologically active compounds, potentially leading to the discovery of innovative treatments for various diseases and conditions.
Used in Chemical Research:
In chemical research, 5-Amino-6-methylisoquinolin-1(2H)-one serves as a model for studying the properties and reactions of isoquinolinone derivatives, contributing to a deeper understanding of the chemistry and potential applications of related compounds.

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 943606-83-5 6-methyl-5-nitroisoquinoline N-oxide 
• 943606-84-6 1-chloro-6-methyl-5-nitroisoquinoline 
• 42398-73-2 6-methylisoquinoline 
• 188121-31-5 6-methyl-5-nitroisoquinoline 
• 943606-85-7 6-methyl-5-nitroisoquinolin-1(2H)-one 

Downstream Products

• 1093101-59-7 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline 
• 1093100-24-3 5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine 
• 1093101-58-6 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one 
• 1093101-60-0 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine 

Relevant academic research and scientific papers

Selective inhibitors of the mutant B-Raf pathway: Discovery of a potent and orally bioavailable aminoisoquinoline

The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is presented. The N-linked pyridylpyrimidine benzamide 2 was identified as a potent, modestly selective inhibitor of the B-Raf enzyme. Replacement of the benzamide with an aminoisoquinoline core significantly improved kinase selectivity and imparted favorable pharmacokinetic properties, leading to the identification of 1 as a potent antitumor agent in xenograft models. 2009 American Chemical Society.

RAF KINASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating the activity of Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula (I) wherein each of A1, A2, A3, A4, A5, A6, A7, A8, A9, bond B, X, rings Z1 and Z2, R1 and R3 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have Formula (I) wherein R1 is Formula (II), (III) or (IV) and A1, A2, A3, A4, X, Z, Z', R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.