943656-83-5Relevant academic research and scientific papers
New isochromans. 1. Synthesis and antimicrobial activity of 4-substituted (±)-1H-spiro[benzo[c]pyran-3(4H), 1′-cyclohexane]-1-ones
Bogdanov, Milen G.,Gocheva, Blagovesta T.,Dimitrova, Darina B.,Palamareva, Mariana D.
, p. 673 - 677 (2008/09/17)
(Chemical Equation Presented) The reaction between homophthalic anhydride and cyclohexanone was examined both in the presence of DMAP or BF 3?Et2O complex as a catalyst. The latter yielded (±)-1-oxo-1H-spiro[benzo[c]pyran-3(4H), 1′-cyclohexane]-4- carboxylic acid (3) in a higher yield (82 %). A series of new (±)-4-(N,N-disubstituted-1-carbamoyl)-1H-spiro[benzo[c]pyran-3(4H), 1′-cyclohexane]-1-ones (5a-h) were synthesized from the parent acid 3 by a two-step reaction. Differentiating microbial screening was performed for most of the synthesized compounds against twelve microorganisms belonging to different taxonomic groups. The spiro acid 3 was active against all bacterial strains with MIC ≤ 20 μg/ml against B. subtillis and P. vulgaris. E. coli was the most sensitive strain to the antibacterial effect of the tested compounds.
