943783-51-5

Basic information

• Product Name: ethyl 3-bromo-4-((2-formamidophenoxy)methyl)benzoate
• Synonyms: ethyl 3-bromo-4-((2-formamidophenoxy)methyl)benzoate
• CAS NO: 943783-51-5
• Molecular Weight: 378.222
• Mol File: 943783-51-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-bromo-4-((2-formamidophenoxy)methyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-bromo-4-((2-formamidophenoxy)methyl)benzoate(943783-51-5)
• EPA Substance Registry System: ethyl 3-bromo-4-((2-formamidophenoxy)methyl)benzoate(943783-51-5)

Safety Data

• Hazardous Substances Data: 943783-51-5(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 943783-50-4 ethyl 4-((2-aminophenoxy)methyl)-3-bromobenzoate 
• 943783-49-1 ethyl 3-bromo-4-((2-nitrophenoxy)methyl)benzoate 
• 7697-26-9 3-bromo-4-methylbenzoic acid 
• 147962-81-0 ethyl 3-bromo-4-methylbenzoate 
• 113641-88-6 3-bromo-4-bromomethyl-benzoic acid ethyl ester 

Relevant articles and documents

Synthesis and structure-activity relationship of tricyclic carboxylic acids as novel anti-histamines

A series of tricyclic carboxylic acids having 6-amino-pyrimidine-2,4(1H,3H) -dione with piperazino or homopiperazino moiety linked by propylene, were synthesized and evaluated for their affinity toward human histamine H 1 receptor and Caco-2 cell permeability. Selected compounds were further evaluated for their oral anti-histaminic activity in mice, bioavailability in rats, and their anti-inflammatory activity in mice OVA-induced biphasic cutaneous reaction model. Among the compounds tested, dibenzoxazepine carboxylic acid 13b showed both histamine H1 receptor antagonistic activity and anti-inflammatory activity in vivo. In addition, 13b exhibited low affinity toward α1 receptor and low occupancy of H1 receptor in the brain. It is therefore, believed that 13b is a potential candidate for development as 3rd generation anti-histamine.