943897-99-2Relevant academic research and scientific papers
Studies toward the total synthesis of sorangiolides and their analogues. A convergent stereoselective synthesis of the macrocyclic lactone precursors
Das, Sanjib,Abraham, Sunny,Sinha, Subhash C.
, p. 2273 - 2276 (2008/02/04)
Stereosetective synthesis of the fully protected 18-membered macrocyclic lactones as the immediate precursors of the natural products, sorangiolides A and B, is described. The key steps used in the synthesis include the sp 3-hybridized carbon-carbon Fu cross coupling, the stereosetective Evans' aldol reaction with 1,5-anti induction, the 1,3-diastereoselective syn reduction of a β-hydroxyketone intermediate, and Mukaiyama macrolactonization reactions.
